Summary
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1.
Mytilus pedal ganglion contains a small population of glial cells that are immunopositive for interleukin-1α. Positively stained fibers can also be seen in the neuropil of these sections.
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The marine wormNereis diversicolor also exhibits positive neural immunostaining for interleukin-1α.
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Both organisms contain hemocytes that contain immunoactivity for interleukin-1α. The study suggests interleukin-1α to be an ancient cytokine given its presence in organisms that evolved significantly earlier than mammals.
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Paemen, L.R., Porchet-Hennere, E., Masson, M. et al. Glial localization of interleukin-1α in invertebrate ganglia. Cell Mol Neurobiol 12, 463–472 (1992). https://doi.org/10.1007/BF00711547
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DOI: https://doi.org/10.1007/BF00711547