Summary
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1.
Met-enkephalin is degraded by peptidases present in the hemolymph fluid and hemocyte membrane suspension ofMytilus edulis. Degradation of Metenkephalin is rapid in the fluid and slower in the membrane.
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2.
Aminopeptidase activity is bestatin sensitive in hemocyte membrane and highest in the fluid of the hemolymph, which appears to have a component which is insensitive to inhibitor.
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3.
ACE activity is found only in the fluid of the hemolymph.
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4.
Carboxypeptidase and NEP (CD10: “enkephalinase”) are membrane bound and the former appears to predominate. Phosphoramidon inhibits not only NEP, as expected, but the invertebrate carboxypeptidase as well.
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Abbreviations
- ACE:
-
angiotensin converting enzyme
- NEP:
-
neutral endopeptidase 24.11
- Y:
-
tyrosine
- G:
-
glycine
- F:
-
phenylalanine
- M:
-
methionine
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Leung, M.K., Le, S., Houston, S. et al. Degradation of met-enkephalin by hemolymph peptidases inMytilus edulis . Cell Mol Neurobiol 12, 367–378 (1992). https://doi.org/10.1007/BF00711539
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DOI: https://doi.org/10.1007/BF00711539