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Neuropeptide Y inhibits human and invertebrate immunocyte chemotaxis, chemokinesis, and spontaneous activation

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Summary

  1. 1.

    In a concentration-dependent manner neuropeptide Y was found to be a potent inhibitor of the spontaneous activation of human granulocytes and macrophages as well asMytilus edulis immunocytes.

  2. 2.

    Neuropeptide Y also inhibited the chemotaxic response of these immunocytes to the chemoattractant f-MLP.

  3. 3.

    Incubation of both the human and the invertebrate immunocytes in f-MLP (10−9 M) causes “activation” as noted by random locomotion (chemokinesis). Neuropeptide Y also blocked f-MLP-induced chemokinesis.

  4. 4.

    The results suggest that neuropeptide Y may, in addition to other functions, serve as an endogenous regulator of immunocyte function.

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Authors and Affiliations

  1. Multidisciplinary Center for the Study of Aging, Old Westbury Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, Old Westbury, New York, USA

    Paul Dureus, Dahla Louis, Anthony V. Grant, Thomas V. Bilfinger & George B. Stefano

  2. Department of Surgery, Health Sciences Center, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA

    Thomas V. Bilfinger & George B. Stefano

  3. Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, Old Westbury, New York, USA

    George B. Stefano

Authors
  1. Paul Dureus
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  2. Dahla Louis
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  3. Anthony V. Grant
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  4. Thomas V. Bilfinger
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  5. George B. Stefano
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Dureus, P., Louis, D., Grant, A.V. et al. Neuropeptide Y inhibits human and invertebrate immunocyte chemotaxis, chemokinesis, and spontaneous activation. Cell Mol Neurobiol 13, 541–546 (1993). https://doi.org/10.1007/BF00711462

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  • DOI: https://doi.org/10.1007/BF00711462

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