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Evidence for a dopaminergic mechanism for the diuretic and natriuretic action of centrally administered atrial natriuretic factor

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Summary

  1. 1.

    Intracerebroventricular (IVT) adminsitration of rat atrial natriuretic factor (ANF) (99-126) to conscious male hydrated rats induces a dose-dependent increase in urine and sodium excretion. The possible involvement of brain dopaminergic system in the IVT-ANF-induced diuresis and natriuresis was evaluated.

  2. 2.

    Central sympathectomy (6-OHDA, 250µg/5µl, IVT; 72 and 48 hr before IVT-ANF) inhibited both the diuretic and the natriuretic action of centrally administered ANF, suggesting that in the brain ANF requires the integrity of central noradrenergic and/or dopaminergic systems function for its actions.

  3. 3.

    Intracerobroventricular injection of haloperidol and intragastric administration of domperidone prevent the diuretic and natriuretic response to centrally administered ANF.

  4. 4.

    Our data suggest a neuromodulatory action of ANF within the brain and demonstrate an interaction of the peptide with brain dopaminergic systems.

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Biological Science, Universidad Central de Venezuela, Sabana Grande 1050 A, Apartado Postal 50176, Caracas, Venezuela

    Anita Israel, Marysabel Torres & Yarisma Barbella

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  1. Anita Israel
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  2. Marysabel Torres
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  3. Yarisma Barbella
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Israel, A., Torres, M. & Barbella, Y. Evidence for a dopaminergic mechanism for the diuretic and natriuretic action of centrally administered atrial natriuretic factor. Cell Mol Neurobiol 9, 369–378 (1989). https://doi.org/10.1007/BF00711416

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  • DOI: https://doi.org/10.1007/BF00711416

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