Journal of Inherited Metabolic Disease

, Volume 16, Issue 1, pp 127–134 | Cite as

The effect of lovastatin on very low-density lipoprotein apolipoprotein B production by the liver in familial combined hyperlipidaemia

  • J. A. Cortner
  • M. J. Bennett
  • N. -A. Le
  • P. M. Coates


Overproduction of very low-density lipoprotein apolipoprotein B by the liver is a metabolic marker for familial combined hyperlipidaemia, a common inherited disorder of lipoprotein metabolism. Four subjects with familial combined hyperlipidaemia had rates of apolipoprotein B production which were 2–7 times normal, using a protocol in which [15N]nglycine was used to label newly synthesized hepatic proteins. Following 4–6 months of therapy with lovastatin, very low-density lipoprotein apolipoprotein B production in all four subjects had returned to the normal range. This demonstrates that lovastatin, an inhibitor of cholesterol biosynthesis, acts also to reduce the apparent production rate of apolipoprotein B by the liver.


Public Health Cholesterol Internal Medicine Production Rate Lovastatin 
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Copyright information

© Society for the Study of Inborn Errors of Metabolism and Kluwer Academic Publishers 1993

Authors and Affiliations

  • J. A. Cortner
    • 1
    • 2
  • M. J. Bennett
    • 3
  • N. -A. Le
    • 4
  • P. M. Coates
    • 1
    • 2
  1. 1.Lipid-Heart Research CenterThe Children's Hospital of PhiladelphiaPhiladelphiaUSA
  2. 2.Department of PediatricsUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Metabolic Disease CenterBaylor University Medical CenterDallasUSA
  4. 4.Division of Arteriosclerosis and Lipid Metabolism, Department of MedicineEmory UniversityAtlantaUSA

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