Summary
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1.
The effects of ionophoretically appliedN-methyl-dl-aspartate (NMDA) and aspartate on identified pyramidal neurons in rat piriform cortex were examined in isolated, submerged, and perfused brain slices.
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2.
NMDA was more potent than aspartate in eliciting neuronal discharge. Perfusion of the acidic amino acid antagonists,dl-2-amino-5-phosphonovalerate (APV), 10−6 or 10−5 M,dl-2-amino-7-phosphonoheptanoate (APH), 10−5 M, andγ-d-glutamylglycine (γDGG), 10−5 M, selectively blocked the response to NMDA without effect on the response to aspartate.
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At higher concentrations which blocked responses to both NMDA and aspartate,γDGG blocked kainate responses and depressed glutamate and quisqualate responses.
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4.
These results suggest that in piriform neurons NMDA and aspartate act at distinct receptor sites, not a common receptor site, and that both of these sites are distinct from those that mediate responses to glutamate, quisqualate, and kainate.
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ffrench-Mullen, J.M.H., Hori, N. & Carpenter, D.O. N-methyl-d-aspartate andl-aspartate activate distinct receptors in piriform cortex. Cell Mol Neurobiol 4, 185–190 (1984). https://doi.org/10.1007/BF00711004
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DOI: https://doi.org/10.1007/BF00711004