Summary
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1.
The effects of cholinomimetics on the release and uptake ofl-glutamic acid have been studied by means of local superfusion of rat neostriatum (in vivo) and using striatum slices (in vitro).
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2.
Cholinomimetics regulate the release ofl-glutamic acid through both muscarinic (m-) and nicotinic (n-) choline receptors according to the mechanism of negative feedback.
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3.
Cholinomimetics regulate release through presynaptic receptors.
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4.
The effect ofn-cholinomimetics is mediated by neostriatum interneurons.
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Godukhin, O.V., Budantsev, A.Y., Selifanova, O.V. et al. Effect of cholinomimetics on the release and uptake ofl-[3H] glutamic acid in rat neostriatum. Cell Mol Neurobiol 4, 117–124 (1984). https://doi.org/10.1007/BF00710999
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DOI: https://doi.org/10.1007/BF00710999