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Psychopharmacologia

, Volume 6, Issue 1, pp 49–56 | Cite as

Some effects of morphine and amphetamine on intellectual functions and mood

  • Wayne O. Evans
  • Richard P. Smith
Original Investigations

Summary

Four groups of 15 undergraduate students received either 10 mg of d-amphetamine sulfate, 16 mg of morphine sulfate, a mixture of 16 mg of morphine sulfate and 10 mg of d-amphetamine sulfate, or a lactose placebo under double blind conditions. These subjects were given, both before and after the administration of the drugs, a series of tests utilizing the Guilford structure of intellect model, the Nowlis and Nowlis mood adjective check list, and the McClelland Need Achievement Scale. It was shown that certain tests were differentially effected by the drugs. Of particular interest was an enhancement by morphine of all tests which were based upon a logical judgment and selection of an answer among a limited number of alternatives. D-amphetamine was found to enhance the performance on scales different from those most enhanced by morphine. It was found that d-amphetamine enhanced the need to achieve and elevated the sense of activation of the subjects. These results were discussed in terms of possible theoretical consequences.

Keywords

Placebo Morphine Lactose Amphetamine Undergraduate Student 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Calloway, E., andG. C. Stone: Re-evaluating focus of attention.L. Uhr andJ. G. Miller (Eds.), Drugs and Behavior. New York: John Wiley & Sons 1960.Google Scholar
  2. Carl, G. P., andW. D. Turner: The effects of benzedrine sulfate (amphetamine sulfate) on performance in a comprehensive psychometric examination. J. Psychol.8, 165–216 (1939).Google Scholar
  3. Evans, W. O.: The synergism of autonomie drugs on opiate or opioid-induced analgesia: A discussion of its potential utility. Milit. Med.127, 1000–1003 (1962).Google Scholar
  4. —, andA. Jewett: The effect of some centrally acting drugs on disjunctive reaction time. Psychopharmacologia (Berl.)3, 124–127 (1962).Google Scholar
  5. Guilford, J. P.: Structure of intellect. Psychol. Bull.53, 267–293 (1956).Google Scholar
  6. —, andP. R. Merrifield: The structure of intellect model: Its uses and implications. Rep. Psychol. Lab., No 24, Los Angeles, University of Southern California 1960.Google Scholar
  7. Haertzen, C. A., H. E. Hill, andR. E. Belleville: Development of the Addiction Research Center Inventory (ARCI): Selection of items that are sensitive to the effects of various drugs. Psychopharmacologia (Berl.)4, 155–167 (1963).Google Scholar
  8. Hurst, P. M.: The effects of d-amphetamine on risk taking. Psychopharmacologia (Berl.)3, 283–291 (1962).Google Scholar
  9. Kornetsky, C., O. Humphries, andE. V. Evarts: Comparison of psychological effects of certain centrally acting drugs in man. Arch. Neurol. Psychiat. (Chic.)77, 318–324 (1956).Google Scholar
  10. Levine, A., H. A. Abramson, M. R. Kaufman, andS. Markham: Lysergic acid diethylamide (LSD-25): The effect on intellectual functioning as measured by Wechser-Bellevue intelligence scale. J. Psychol.40, 385–395 (1955).Google Scholar
  11. Lindquist, E. F.: Design and analysis of experiments on psychology and education. Boston: Houghton Mifflin Company 1956.Google Scholar
  12. McClelland, D. C., J. W. Atkinson, R. A. Clark, andE. L. Lowell: The achievement motive. New York: Appleton-Century Crofts 1953.Google Scholar
  13. Molitch, M., andJ. P. Sullivan: Effect of benzedrine sulfate on children taking a new Stanford achievement test. Amer. J. Orthopsychiat.7, 519–522 (1937).Google Scholar
  14. Nash, H.: Psychologic effects of amphetamine and barbiturates. J. nerv. ment. Dis.134, 203–217 (1962).Google Scholar
  15. Nowlis, V., andHelen Nowlis: The description and analysis of mood. Ann. N.Y. Acad. Sci.65, 345–355 (1956).Google Scholar
  16. Siegel, S.: Level of aspiration and decision making. Psychol. Rev.64, 253–263 (1957).Google Scholar
  17. Smith, G. M., andH. K. Beecher: Measurement of “mental clouding” and other subjective effects of morphine. J. Pharmacol. exp. Ther.126, 50–61 (1959).Google Scholar
  18. —,M. Weitzner, Sandra R. Levenson, andH. K. Beecher: Effects of amphetamine and secobarbital on coding and mathematical performance. J. Pharmacol. exp. Ther.141, 100–104 (1963).Google Scholar
  19. Wade, J.: The effect of sedatives upon responses in monkeys following removal of the prefrontal lobes. J. Neurophys.10, 57–66 (1947).Google Scholar

Copyright information

© Springer-Verlag 1964

Authors and Affiliations

  • Wayne O. Evans
    • 1
    • 2
  • Richard P. Smith
    • 1
    • 2
  1. 1.Division of PsychologyUS Army Medical Research LaboratoryFort Knox
  2. 2.Department of Pharmacology, School of MedicineUniversity of LouisvilleLouisville

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