Summary
This paper deals with the paramyxovirus-like intranuclear inclusions observed in giant cells tumours of bone (GCTB). Twenty-one (49%) of 43 cases of GCTB (1977–1985), either fresh and/ or cultured, show these ultrastructural inclusions.
Fifty samples of various bone lesions in which giant cell lesions occurred, including aneurysmal cysts, hyperparathyroidism, osteoblastoma, human and rat osteopetrosis, GCT of tendon sheaths, and non skeletal granuloma were used as controls. These, together with 20 samples of normal bone (osteoclasts) did not contain intranuclear or intracytoplasmic viral inclusions.
Similar content being viewed by others
References
Abelanet R, Forest M, Vacher-Lavenu MC, Carlioz A, Daudet-Monsac M (1982) Inclusions paramyxovirus-like intranucléaires dans les tumeurs à celloles géantes des os. Leur parenté avec celles des ostéoclastes de la Maladie osseuse de Paget. “R” Rev Int Rhum XII:159–166
Aparisi T, Arborgh B, Ericsson JLE (1979) Giant cell tumor of bone. Variations in patterns of appearance of different cell types. Virchows Arch [Pathol Anat] 381:159–178
Basle MF, Fournier JG, Rozenblatt S, Rebel A (1986) Detection of Measles Virus RNA in pagetic bone cells by in situ hybridization. Calcif Tissues Int [Suppl S30] (Abstr 111)
El Labban NG (1984) Ultrastructural study of intranuclear tubulo-filaments in a giant cell tumor of bone in a patient with Paget“s disease. J Oral Pathol 13:650–660
Erlandson RA (1981) In Erlandson RA: Diagnostic transmission electron microscopy of human tumors. The interpretation of submicroscopic structures in human neoplastic cells. Masson Publishing Inc, New York, Paris, pp 77–90
Gherardi G, Lo Cascio V, Bonucci E (1980) Fine structure of nuclei and cytoplasm of osteoclasts in Paget's disease of bone. Histopathology 4:63–74
Giorkey E, Sinkovics JG, Giorkey P (1971) Electron microscopic observations on structure resembling myxovirus in human sarcomas. Cancer 27:1449–1454
Hanaoka H, Friedman B, Mack RP (1971) Ultrastructure and histogenesis of giant cell tumor of bone. Cancer 25:1408–1423
Howatson AF, Fornasier VL (1982) Microfilaments associated with Paget's disease of bone: Comparison with nucleocapsids of measles virus and respiratory syncitial virus. Intervirology 18:150–159
Kuwana K (1967) Electron microscopicstudy on giant cell tumor of bone. Arch Jpn Chir 36:819–847
Le Charpentier Y, Le Charpentier M, Forest M, Daudet-Monsac M, Vacher-Lavenu MC, Louvel A, Sedel L, Abelanet R (1977) Inclusions intranucléaires dans une tumeur osseuse à cellules géantes. Mise en évidence au microscope électronique. Nouv Presse Med 6:259–262
Mills BG, Singer FR, Weiner LP, Holst PA (1979) Long tissue culture of cells from bone affected by Paget's disease. Calcif Tissues Int 29:79–87
Mills BG, Singer FR, Weiner LP, Holst PA (1980) Cell cultures from bone affected by Paget's disease. Arthritis Rheum 23:1115–1119
Morgan-Capner P, Robinson P, Clewley G, Darby A, Pettingale K (1981) Measles antibody in Paget's disease. Lancet 1:733
Rebel A, Malkani K, Basle M (1974) Anomalies nucléaires de la Maladie osseuse de Paget. Nouv Presse Med 3:1299–1301
Rebel A, Basle M, Pouplard A, Kouyomdjian S, Filmon R, Lepatezour A (1980) Viral antigen in osteoclasts from Paget's disease of bone. Lancet (8190) 2:344–346
Rebel A, Basle M (1981) Maladie osseuse de Paget et virus. Ann Pathol 1:21–26
Schajowicz F, Ubios AM, Santini Araujo E, Cabrini L (1985) Virus like intranuclear inclusions in giant cell tumor of bone. Clin Orthop 201:247–250
Singer FR, Mills BG (1983) Evidence for a viral etiology of Paget's disease of bone. Clin Orthop 178:245–251
Thiery JP, Mazabraus A, Voisin MC, Lacroix G (1975) Etude cytologique de la tumeur à cellules géantes. Microscopie électronique. Rev Chir Orthop 61:377–386
Vacher-Lavenu MC, Louvel A, Daudet-Monsac M, Abelanet R (1980) Configuration et position des centrioles des cellules mono et multinucléées des tumeurs à cellules géantes des os longs. Ann Anat Pathol 25:331–339
Vacher-Lavenu MC, Louvel A, Daudet-Monsac M, Le Charpentier Y, Abelanet R (1981) Inclusions tubulo-filamenteuses intranucléaires dans les cellules multinculéées des tumeurs à cellules géantes des os. Etude ultrastructurale d'une série de 31 tumeurs. CR Acad Sci (Paris) 293:639–644
Welsh RA, Mayer AT (1970) Nuclear fragmentations and associated fibrils in giant cell tumor of bone. Lab Invest 22:63–72
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Abelanet, R., Daudet-Monsac, M., Laoussadi, S. et al. Frequency and diagnostic value of the virus-like filamentous intranuclear inclusions in giant cell tumor of bone, not associated with Paget's disease. Vichows Archiv A Pathol Anat 410, 65–68 (1986). https://doi.org/10.1007/BF00710907
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00710907