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Virchows Archiv A

, Volume 410, Issue 1, pp 65–68 | Cite as

Frequency and diagnostic value of the virus-like filamentous intranuclear inclusions in giant cell tumor of bone, not associated with Paget's disease

A study of 43 cases
  • René Abelanet
  • Monique Daudet-Monsac
  • Saddek Laoussadi
  • Michel Forest
  • Marie-Cécile Vacher-Lavenu
Article

Summary

This paper deals with the paramyxovirus-like intranuclear inclusions observed in giant cells tumours of bone (GCTB). Twenty-one (49%) of 43 cases of GCTB (1977–1985), either fresh and/ or cultured, show these ultrastructural inclusions.

Fifty samples of various bone lesions in which giant cell lesions occurred, including aneurysmal cysts, hyperparathyroidism, osteoblastoma, human and rat osteopetrosis, GCT of tendon sheaths, and non skeletal granuloma were used as controls. These, together with 20 samples of normal bone (osteoclasts) did not contain intranuclear or intracytoplasmic viral inclusions.

Key words

Giant-cell Virus-like inclusion Intranuclear inclusion Giant cell tumour of bone Paget's disease of bone Electron microscopy 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • René Abelanet
    • 1
  • Monique Daudet-Monsac
    • 1
  • Saddek Laoussadi
    • 1
  • Michel Forest
    • 1
  • Marie-Cécile Vacher-Lavenu
    • 1
  1. 1.Service Central d'Anatomie et Cytologie pathologiquesHopital CochinParis, Cedex 14France

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