Virchows Archiv A

, Volume 406, Issue 1, pp 1–5 | Cite as

Granular cell tumors contain myelin-associated glycoprotein

An immunohistochemical study using Leu 7 monoclonal antibody
  • J. Smolle
  • K. Konrad
  • H. Kerl


An immunohistochemical staining procedure using Leu 7 (HNK-1) monoclonal antibody was used to study the distribution of myelin-associated glycoprotein in granular cell tumours. Positive reactions were noted in 10 of the 13 tumours investigated. This observation supports the concept that granular cell tumours are of Schwann cell origin.

Key words

Granular cell tumor Myelin-associated glycoprotein Leu-7 antibody 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abo T, Balch CM (1981) A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol 127:1024–1029Google Scholar
  2. Abrikossoff A (1926) Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur. Virch Arch [Pathol Anat] 26:215–233Google Scholar
  3. Armin A, Connelly EM, Rowden G (1983) An immunoperoxidase investigation of S 100 protein in granular cell myoblastomas: evidence for Schwann cell derivation. Am J Clin Pathol 79:37–44Google Scholar
  4. Bedetti CD, Martinez AJ, Beckford NS, May M (1983) Granular cell tumor arising in myelinated peripheral nerves. Light and electron microscopy and immunoperoxidase study. Virch Arch [Pathol Anat] 402:175–183Google Scholar
  5. Enzinger FM, Weiss SW (1983) Soft tissue tumors. Mosby CV Company St. Louis, Toronto, London, pp 745–53Google Scholar
  6. Feyrter F (1935) Über eine eigenartige Geschwulstform des Nervengewebes im menschlichen Verdauungsschlauch. Arch Pathol Anat 195:480–501Google Scholar
  7. Fisher ER, Wechsler H (1962) Granular cell myoblastoma is a misnomer. Electron microscopic and histochemical evidence concerning its Schwann cell derivation and nature (granular cell schwannoma). Cancer 15:936–944Google Scholar
  8. Huber H, Pastner D, Gabl F (1983) Laboratoriumsdiagnose 1 häimatologischer Erkrankungen. Hämatologie und Immunhämatologie. Springer, Berlin, Heidelberg, New York, TokyoGoogle Scholar
  9. Kahn HJ, Baumal R, Marks A (1984) The value of immunohistochemical studies using antibody to S-100 protein in dermatopathology. Int J Dermatol 23:38–44Google Scholar
  10. Köhler G, Milstein C (1975) Continous cultures of fused cells secreting antibody of predifined specificity. Nature 256:495Google Scholar
  11. Lipinski M, Braham K, Cailloud JM, Carlu C, Tursz T (1983) HNK-1 antibody detects an antigen expressed on neuroectodermal cells. J Exp Med 158:1775–1780Google Scholar
  12. McGarry RC, Helfand SL, Quarles RH, Roder JC (1983) Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1. Nature 306:376–378Google Scholar
  13. Penneys NS, Adachi K, Ziegels-Weissman J, Nadji M (1983) Granular cell tumors of the skin contain myelin basic protein. Arch Pathol Lab Med 107:302–303Google Scholar
  14. Schuller-Petrovic S, Gebhart W, Lassmann H, Rumpold H, Kraft D (1983) A shared antigenic determinant between natural killer cells and nervous tissue. Nature 306:179–181Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • J. Smolle
    • 1
  • K. Konrad
    • 2
  • H. Kerl
    • 1
  1. 1.Department of DermatologyUniversity of GrazAustria
  2. 2.Department of Dermatology (I)University of ViennaAustria

Personalised recommendations