Summary
Light and electron microscope studies of the ear cartilage in a patient with relapsing polychondritis (RP) under corticoid treatment are reported. Unilateral auricular deformation evolved without inflammatory episodes and the lesions consisted mainly of marginal erosions filled with fine collagen fibrils and containing degenerating perichondrial cells in their basal parts. Degenerative cells were scattered throughout the perichondrium, but cartilage erosions only occured when numerous cells were affected in a same area. Cartilage outside the eroded zones did not seem to be modified. Cartilage lesions thus appear to be a result of a chondrocyte renewal defect leading to loss of proteoglycans and elastic fibers, with only collagen remaining. These data suggest that inflammation is probably not the initial pathogenic process responsible for cartilage injury in RP, but that a metabolic defect in perichondrial cells might be involved.
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References
Arkin CR, Masi AP (1975) Relapsing polychondritis: review of current status and case report. Semin Arthritis Rheum 5:41–62
Dolan DL, Lemmon GB, Teitelbaum SL (1966) Relapsing polychondritis. Am J Med 41:285–299
Feinerman LK, Johnson WC, Weiner J, Graham JH (1970) Relapsing polychondritis: A histopathologic and histochemical study. Dermatologica 140:369–377
Grimaud R, Bodelet B (1973) Polychondrite chronique atrophiante: ultrastructure des lésions cartilagineuses au niveau du pavillon de l'oreille. Acta Otolaryng 75:104–111
Hashimoto K, Arkin CR, Kang AH (1977) Relapsing polychondritis. An ultrastructural study. Arthritis Rheum 20:91–99
Hance AJ, Crystal RG (1975) The connective tissue of lung. Am Rev Respir Dis 112:657–711
Herman JH, Dennis MV (1973) Immunopathologic studies in relapsing polychondritis. J Clin Invest 52:549–558
Hughes RAC, Berry CL, Seifert M (1972) Relapsing polychondritis. Three cases with a clinico-pathological study and literature review. QJ Med 41:363–380
Ishihara T, Iwata T, Furutani H, Uchino F, Maeda S, Mogi G, Honjo S (1973) Relapsing polychondritis: Report of a case with ultrastructural findings of the ear cartilage. Acta Pathol Jap 23:577–590
Maroudas A (1970) Distribution and diffusion of solutes in articular cartilage. Biophys J 10:365
Mitchell N, Shepard M (1972) Relapsing polychondritis: an electron microscopic study of synovium and articular cartilage. J Bone Joint Surg 54A: 1235–1245
Rajapakse DA, Bywaters EGL (1974) Cell mediated immunity to cartilage proteoglycan in relapsing polychondritis. Clin Exp Immunol 16:497–502
Rogers PH, Boden MG, Tourtellote CD (1973) Relapsing polychondritis with insulin resistance and antibodies to cartilage. Am J Med 55:243–248
Schaul SR, Schumacher HR (1975) Relapsing polychondritis: electron microscopic study of ear cartilage. Arthritis Rheum 18:617–625
Silbert JE (1973) Biosynthesis of mucopolysaccharides and potein-polysaccharides. In: Perez-Tamayo R, Rojkind M (eds) Molecular pathology of connective tissues. M Dekker, Inc New York pp 323–353
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This work was carried out with a grant from the INSERM, CRL No 79. 1 218 4
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Linck, G., Porte, A., Mantz, J.M. et al. Light and electron microscopic study of ear cartilage in a case of relapsing polychondritis evolving under corticoid treatment. Virchows Arch. A Path. Anat. and Histol. 391, 301–308 (1981). https://doi.org/10.1007/BF00709162
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DOI: https://doi.org/10.1007/BF00709162