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HPLC Separation of the atropisomers of some substitutedN-Arylthiazoline-2-Thiones withγ-Cyclodextrin as a chiral mobile phase additive: Size and lipophilicity effects of substitutents

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Abstract

The chromatographic separations of some substitutedN-arylthiazoline-2-thione atropisomers are described, using reversed-phase HPLC withγ-cyclodextrin as a chiral mobile phase additive. The effects of the size and lipophilicity of various substituents are discussed and emphasize the close relationship between inclusion inside the cyclodextrin cavity and the chromatographic selectivity.

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Authors and Affiliations

  1. Faculté Sciences St. Jérôme, URA 1410 CNRS, ENSSPICAM, 13397, Marseille Cedex 20, France

    C. Roussel

  2. Société Roquette Frères, 62136, Lestrem, France

    A. Favrou

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  1. C. Roussel
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  2. A. Favrou
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Roussel, C., Favrou, A. HPLC Separation of the atropisomers of some substitutedN-Arylthiazoline-2-Thiones withγ-Cyclodextrin as a chiral mobile phase additive: Size and lipophilicity effects of substitutents. J Incl Phenom Macrocycl Chem 16, 283–296 (1993). https://doi.org/10.1007/BF00708798

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  • DOI: https://doi.org/10.1007/BF00708798

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