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Increasing the solubility characteristics of fenofibrate with cyclodextrin

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Abstract

The incidence of genetic lipoprotein disorders, or hyperlipoproteinaemia, is currently increasing. Examinations were carried out on the hyperlipoproteinaemic drug fenofibrate and various cyclodextrin derivatives were applied to increase the solubility of this drug. Numerous products with several compositions (drug: CD mole ratio=2:1, 1:1, 1:2 or 1:3) were studied and three preparation methods (powder mixing, kneading and precipitation) were used. In vitro drug liberation and membrane diffusion examinations revealed compositions suitable for the preparation of a capsule dosage form (1:2 and 1:3 physical mixtures).

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Albert Szent-Györgyi Medical University, P.O. Box 121, H-6701, Szeged, Hungary

    Zoltán Aigner, Ingrid Bencz & Michael Kata

Authors
  1. Zoltán Aigner
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  2. Ingrid Bencz
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  3. Michael Kata
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Additional information

Dedicated to Dr. Béla Selmeczi, university professor, with the best wishes for his 65th birthday.

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Aigner, Z., Bencz, I. & Kata, M. Increasing the solubility characteristics of fenofibrate with cyclodextrin. J Incl Phenom Macrocycl Chem 20, 241–252 (1994). https://doi.org/10.1007/BF00708770

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  • DOI: https://doi.org/10.1007/BF00708770

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