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Virchows Archiv A

, Volume 409, Issue 3, pp 349–363 | Cite as

Localized fibrous tumour of serosal surfaces

Immunohistochemical and ultrastructural evidence for a type of mesothelioma
  • John Doucet
  • Irving Dardick
  • John R. Srigley
  • A. W. Peter van Nostrand
  • M. Adeline Bell
  • Harriette J. Kahn
Article

Summary

It is uncertain whether localized lesions of serosal membranes have a kinship to mesotheliomas or are truly fibromatous in nature. Ultrastructural and immunohistochemical investigations were carried out on 12 localized benign and malignant pleural and peritoneal tumours from 10 patients. Electron microscopic findings, including the consistent and non-fibroblastic cellular organization of localized neoplasms, the presence of some form of intercellular junctions in 7 of 10 cases, basal lamina deposition in 3 cases, and polarized microvilli in one case indicated a form of mesothelial differentiation. Using monoclonal and polyclonal antibodies, positive immunostaining of tumour cells for cytokeratin peptides was detected in one case, while antibody to vimentin stained four cases. Light microscopic, ultrastructural and immunohistochemical features of one benign localized serosal tumour, with a unique blend of epithelial and spindle cells, provided further evidence for a histogenic link between localized serosal tumours and diffuse epithelial mesotheliomas. On the basis of the current findings and reports in the literature, it would appear that the majority of localized tumours of serosal membranes are a subset of mesothelioma, while a minority are fibromas.

Key words

Mesothelioma Serous membrane Localized tumour Histogenesis Ultrastructure 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • John Doucet
    • 1
  • Irving Dardick
    • 4
  • John R. Srigley
    • 1
  • A. W. Peter van Nostrand
    • 1
  • M. Adeline Bell
    • 2
  • Harriette J. Kahn
    • 3
  1. 1.Departments of PathologyToronto General HospitalToronto, Ontario
  2. 2.University of OttawaOttawa, Ontario
  3. 3.Women's College Hospital and The Hospital for Sick ChildrenToronto, OntarioCanada
  4. 4.Canadian Tumour Reference CentreOttawa, OntarioCanada

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