Summary
Renal blood flow was measured in rats anaesthetized with pentobarbital sodium by employing the PAH clearance method and the133Xe washout technique. Both methods were in good agreement. In 17 rats a 25% decrement of blood pressure was attained through haemorrhage; RBF measured by PAH clearance declined by 3%, according to133Xe washout by 2.7%. In further 21 rats an increase of blood pressure by an average of 265 was achieved by occlusion of the carotid arteries; RBF measured by PAH clearance declined by 3%, according to133Xe washout by 1.1%. RBF was therefore almost perfectly autoregulated during both experimental manoeuvres; glomerular filtration rate (inulin clearance) was autoregulated in a similar manner. Water and sodium excretion changed in proportion to changes of blood pressure.
Similar content being viewed by others
References
Allison, M. E. M., Lipham, E. M., Gottschalk, C. W.: Hydrostatic pressure in the rat kidney. Amer. J. Physiol.223, 975–983 (1972)
Arendshorst, W. J., Finn, W. F., Gottschalk, C. W.: Autoregulation of blood flow in the rat kidney. Amer. J. Physiol.228, 127–133 (1975)
Bank, N., Aynedjian, H. S., Bansal, V. K., Goldman, D. M.: Effect of acute hypertension on sodium transport by the distal nephron. Amer. J. Physiol.219, 275–280 (1970)
Bonvalet, J. P., Bencsáth, P., de Rouffignac, C.: Glomerular filtration rate of superficial and deep nephrons during aortic constriction. Amer. J. Physiol.222, 599–606 (1972)
Bonvalet, J. P., Bencsáth, P., de Rouffignac, C.: Glomerular filtration rate of superficial and juxta-medullary nephrons in the rat during different types of arterial hypertension. Pflügers Arch.340, 133–144 (1973)
Gertz, K. H., Mangos, J. A., Braun, G., Pagel, H. D.: Pressure in the glomerular capillaries of the rat kidney and its relation to arterial blood pressure. Pflügers Arch. ges. Physiol.288, 369–374 (1966)
Hinshaw, L. B.: Mechanism of renal autoregulation: Role of tissue pressure and description of a multifactor hypothesis. Circulat. Res.15, Suppl. I, 120–131 (1964)
Källskog, Ö., Lindbom, L. O., Ulfendahl, H. R., Wolgast, M.: The pressure-flow relationship of different nephron populations in the rat. Acta physiol. scand.94, 289–300 (1975)
Knox, F. G., Ott, C., Cuche, J. L., Gasser, J., Haas, J.: Autoregulation of single nephron filtration rate in the presence and the absence of flow to the macula densa. Circulat. Res.34, 836–842 (1974)
Koch, K. M., Aynedjian, H. S., Bank, N.: Effect of acute hypertension on sodium reabsorption by the proximal tubule. J. clin. Invest.47, 1696–1709 (1968)
Little, J. M.: A modified diphenylamine procedure for the determination of inulin. J. biol. Chem.180, 747–752 (1949)
Loyning, E. W.: Effect of reduced perfusion pressure on intrarenal distribution of blood flow in dogs. Acta physiol. scand.83, 191–202 (1971)
McNay, J. L., Abe, Y.: Pressure-dependent heterogenity of renal cortical blood flow in dogs. Circulat. Res.27, 571–587 (1970)
Ohler, W., Harth, O., Kreienberg, W.: Die Abhängigkeit der Nierendurchblutung vom arteriellen Druck bei der Ratte. Pflügers Arch. ges. Physiol.269, 274–281 (1959)
Schoeppe, W. E., Frey, J.: Pressure in the proximal tubule of the rat kidney and its relation to arterial blood pressure. Proc. of the IIIrd Inter. Nephrol. Congress, 268 (1966)
Selkurt, E. E.: The renal circulation. In: Handbook of Physiology, Circulation, Sect. 2, vol. II, 1457–1516. Washington, D.C.: Am. Physiol. Soc., Ed. 1963
Smith, H. W., Finkelstein, N., Aliminosa, L., Crawford, B., Graber, M.: The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man. J. clin. Invest.24, 388–404 (1945)
Thorburn, G. D., Kopald, H. H., Herd, J. A., Hollenberg, M., O'Morchoe, C. C. C., Barger, A. C.: Intrarenal distribution of nutrient blood flow determined with Krypton85 in the unanaesthetized dog. Circulat. Res.13, 290–307 (1963)
Thurau, K., Weber, E.: Zur Lokalisation der autoregulativen Widerstandsänderungen in der Niere. Mikropunktionsmessungen der Drucke in Tubuli und peritubulären Capillaren der Rattenniere bei Änderungen des arteriellen Druckes. Pflügers Arch. ges. Physiol.274, 553–566 (1962)
Thurau, K.: Renal hemodynamics. Amer. J. Med.36, 698–719 (1964)
Weiss, C., Passow, H., Rothstein, A.: Autoregulation of flow in isolated rat kidney in the absence of red cells. Amer. J. Physiol.169, 1115–1118 (1959)
Author information
Authors and Affiliations
Additional information
with technical assistance of JANA HOLLYOVÁ
Rights and permissions
About this article
Cite this article
Heller, J., Hollyová, J. Autoregulation of renal blood flow in the rat. Pflugers Arch. 370, 81–85 (1977). https://doi.org/10.1007/BF00707950
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00707950