Pflügers Archiv

, Volume 370, Issue 1, pp 19–23 | Cite as

A hypothalamic alpha-adrenergic mechanism mediating the thermogenic response to electrical stimulation of the lower brainstem in the guinea pig

  • Zoltán Szelényi
  • Eugen Zeisberger
  • Kurt Brück
Article

Summary

Electrical stimulation of the lower brain stem (ESLB) at sites presumed to be parts of the ascending noradrenergic system was carried out in unanaesthetized young guinea pigs. At neutral ambient temperature ESLB elicited a thermogenic response resembling that evoked by microinjection of noradrenaline into the hypothalamus. The response consisted of a rise in oxygen uptake (to more than 50% of the resting value) and of body temperatures, especially of the interscapular adipose tissue. In some cases shivering was also evoked. The thermogenic response to ESLB was completely blocked by additional microinjection of an adrenergic alpha-receptor blocker, phentolamine, into the hypothalamic area where the noradrenergic fibres were presumed to terminate. Subsequent intrahypothalamic injection of noradrenaline, which had formerly been shown to restore the decreased responses to repeated ESLB, failed to restore the effectiveness of ESLB after phentolamine. It is concluded that the thermogenic responses to ESLB are mediated by a noradrenergic pathway ascending to the hypothalamus and not by direct stimulation of efferent pathways controlling the peripheral target system. The hypothalamic transmission can be prevented by an alpha-adrenergic blockade.

Key words

Electrical brainstem stimulation Central noradrenergic pathways Adrenergic alpha-receptor blocking agents Central control of thermogenesis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Brück, K., Wünnenberg, W.: Beziehung zwischen Thermogenese im “braunen” Fettgewebe, Temperatur im cervicalen Anteil des Vertebralkanals und Kältezittern. Pflügers Arch. ges. Physiol.290, 167–183 (1966)Google Scholar
  2. 2.
    Brück, K., Wünnenberg, W.: Eine kälteadaptive Modifikation: Senkung der Schwellentemperaturen für Kältezittern. Pflügers Arch. ges. Physiol.293, 226–236 (1967)Google Scholar
  3. 3.
    Brück, K., Wünnenberg, W., Gallmeier, H., Ziehm, B.: Shift of threshold temperature for shivering and heat polypnea as a mode of thermal adaptation. Pflügers Arch.321, 159–172 (1970)Google Scholar
  4. 4.
    Kirpekar, S. M.: Factors influencing transmission at adrenergic synapses. Prog. Neurobiol.4 (3), 163–210 (1975)Google Scholar
  5. 5.
    Kobayashi, R. M., Palkovits, M., Jacobowitz, D. M., Kopin, I. J.: Biochemical mapping of the noradrenergic projection from the locus coeruleus. Neurology (Minneap.)25, 223–233 (1975)Google Scholar
  6. 6.
    Lindvall, O., Björklund, A.: The organization of the ascending catecholamine neuron systems in the rat, as revealed by the glyoxylic acid fluorescence method. Acta Physiol.Scand.92, Suppl. 412 (1974)Google Scholar
  7. 7.
    Roizen M. F.: Biochemical mapping of noradrenergic projections of axons in the dorsal noradrenergic bundle. Brain Res.104, 384 (1976)Google Scholar
  8. 8.
    Szelényi, Z., Zeisberger, E., Brück, K.: Effects of electrical stimulation in the lower brainstem on temperature regulation in the unanaesthetized guinea pig. Pflügers Arch.364, 123–127 (1976)Google Scholar
  9. 9.
    Ungerstedt, U.: Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol. Scand.82, 1–48 (1971)Google Scholar
  10. 10.
    Zeisberger, E., Brück, K.: Central effect of noradrenaline on the control of body temperature in the guinea pig. Pflügers Arch.322, 152–166 (1971)Google Scholar
  11. 11.
    Zeisberger, E., Brück, K.: Alteration of shivering threshold in cold- and warm-adapted guinea pigs following intrahypothalamic injections of noradrenaline and of an adrenergic alpha-receptor blocking agent. Pflügers Arch.362, 113–119 (1976)Google Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Zoltán Szelényi
    • 1
    • 2
  • Eugen Zeisberger
    • 1
  • Kurt Brück
    • 1
  1. 1.Zentrum für Physiologie der Justus-Liebig-Universität GiessenGiessenFederal Republic of Germany
  2. 2.Institute of PathophysiologyUniversity Medical SchoolPécsHungary

Personalised recommendations