Preparation and characterization of theβ-cyclodextrin inclusion complex with sulfafurazole

  • Barbara Szafran
  • Jan Pawlaczyk
Article

Abstract

The 1 : 1 inclusion complex involving sulfafurazole (SF) andβ-cyclodextrin (β-CD) is prepared by the freeze-drying method and characterized on the basis of its chemical analysis, thermal behavior, infrared spectrum, X-ray powder pattern and13C NMR spectrum in DMSO-d6 solution. The stability constant of the inclusion complex was determined by the solubility method. The effect of cyclodextrin on the UV absorption spectrum of sulfafurazole was also observed.

Key words

β-Cyclodextrin complex sulfafurazole freeze-drying kneading thermal analysis UV spectroscopy IR and13C NMR complexation effect 

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Barbara Szafran
    • 1
  • Jan Pawlaczyk
    • 1
  1. 1.Department of Inorganic and Analytical ChemistryK. Marcinkowski University of Medical SciencesPoznańPoland

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