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Development of rib-vertebrae: a new mutation in the house mouse with accessory caudal duplications

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Summary

The new recessive mutation rib-vertebrae (rv) causes fusions of lower ribs and malformations of vertebrae, which results from disturbed somite arrangement. In addition, duplications of the caudal neural tube and sometimes unilateral suppression of kidney formation can be observed. The new mutation is compared with the six already known mutations in mice with “Wirbel-Rippen-Syndrome” and with a similar syndrome in man. From the various effects of the rv-gene observed, it is suggested that the gene causes abnormal inner and outer surface formation, producing manifold secondary effects.

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Authors and Affiliations

  1. Anatomisches Institut der Universität, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland

    Karl Theiler & Don S. Varnum

  2. The Jackson Laboratory, 04609, Bar Harbor, ME, USA

    Karl Theiler & Don S. Varnum

Authors
  1. Karl Theiler
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  2. Don S. Varnum
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Additional information

This work was supported by NIH Research Grant RR 01183

The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care

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Theiler, K., Varnum, D.S. Development of rib-vertebrae: a new mutation in the house mouse with accessory caudal duplications. Anat Embryol 173, 111–116 (1985). https://doi.org/10.1007/BF00707309

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  • DOI: https://doi.org/10.1007/BF00707309

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