Acta Neuropathologica

, Volume 49, Issue 3, pp 169–176 | Cite as

Passive transfer of demyelination by experimental allergic neuritis serum

  • A. F. Hahn
  • J. J. Gilbert
  • T. E. Feasby
Original Works


Serum from rabbits with experimental allergic neuritis (FAN) when injected into rat sciatic nerves produced rapidly evolving demyelination followed by remyelination. Myelinating and non-myelinating Schwann cells as well as myelin itself were damaged by 15 min after injection. Myelin degradation was well advanced prior to involvement by macrophages at 12 h. The demyelinating factor was myelin-specific and complement-dependent. The evidence suggests that the FAN antigen may reside in Schwann cell membranes as well as in myelin.

Key words

Experimental allergic neuritis Demvelination Humoral immunity Myelin Schwann cell 


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  1. Abramsky, O., Teitelbaum, D., Arnon, R.: Experimental allergic neuritis induced by a basic neuritogenic protein (P1L) of human peripheral nerve origin. Eur. J. Immunol.7, 213–217 (1977)Google Scholar
  2. Allt, G., Evans, E. M., Evans, D. H. L.: Experimental allergic neuritis: an assessment of the role of a serum factor in its etiology. Brain Res.32, 255–257 (1971)Google Scholar
  3. Arnason, B. G. W.: Idiopathic polyneuritis (Landry-Guillain-Barré-Strohl Syndrome) and experimental allergic neuritis; a comparison. Res. Publ. Assoc. Res. Nerv. Ment. Dis.49, 157–177 (1971)Google Scholar
  4. Arnason, B. G. W., Chelmicka-Szorc, E.: Passive transfer of experimental allergic neuritis in Lewis rats by direct injection of sensitized lymphocytes into sciatic nerve. Acta Neuropathol. (Berl.)22, 1–6 (1972)Google Scholar
  5. Arnason, B. G. W., Winkler, G. F., Hadler, N. M.: Cell-mediated demyelination of peripheral nerve in tissue culture. Lab. Invest.21, 1–10 (1969)Google Scholar
  6. Astrom, K. E., Webster, H., Arnason, B. G. W.: The initial lesion in experimental allergic neuritis: a phase and electron microscopic study. J. Exp. Med.128, 469–482 (1968)Google Scholar
  7. Astrom, K. E., Waksman, B. G.: The passive transfer of experimental allergic encephalomyelitis and neuritis with living lymphoid cells. J. Path. Bact.83, 89–106 (1962)Google Scholar
  8. Brostoff, S. W., Sacks, H., Dal Canto, M., Johnson, A. B., Raine, C. S., Wisniewski, H.: The P2 protein of bovine root myelin: isolation and some chemical and immunological properties. J. Neurochem.23, 1037–1043 (1974)Google Scholar
  9. Kadlubowski, M., Hughes, R. A. C.: Identification of the neuritogen for experimental allergic neuritis. Nature277, 140–141 (1979)Google Scholar
  10. Kadlubowski, M., Hughes, R. A. C., Gregson, N. A.: Experimental allergic neuritis in the Lewis rat: characterization of the activity of peripheral myelin and its major basic protein P2. Brain Res. (in press) (1980)Google Scholar
  11. London, Y.: Ox peripheral nerve myelin membrane. Purification and partial characterization of two basic proteins. Biochim. Biophys. Acta249, 188–196 (1971)Google Scholar
  12. Mirsky, R., Winter, J., Abney, E. R., Pruss, R. M., Gavrilovic, J., Raff, M. C.: Myelin-specific proteins and glycolipids in rat Schwann cells and oligodendrocytes in culture. J. Cell Biol. (in press) (1980)Google Scholar
  13. Raine, C. S., Bornstein, M. B.: Experimental allergic neuritis: ultrastructure of serum-induced myelin aberrations in peripheral nervous system cultures. Lab. Invest.40, 423–432 (1979)Google Scholar
  14. Saida, T., Saida, K., Silberberg, D. H., Brown, M. J.: Transfer of demyelination by intraneural injection of experimental allergic neuritis serum. Nature272, 639–641 (1978a)Google Scholar
  15. Saida, K., Saida, T., Brown, M. J., Silberberg, D. H., Asbury, A. K.: Antiserum-mediated demyelination in vivo. A sequential study using intraneural injection of experimental allergic neuritis serum. Lab. Invest.39, 449–462 (1978b)Google Scholar
  16. Saida, K., Saida, T., Alving, C. R., Brown, M. J., Silberberg, D. H., Asbury, A. K.: In vivo demyelination produced by purified antibodies to galactocerebroside. J. Neuropathol. Exp. Neurol.38, 338 (1979a)Google Scholar
  17. Saida, T., Saida, K., Dorfman, S. H., Silberberg, D. H., Sumner, A. J., Manning, M. C., Lisak, R. P., Brown, M. J.: Experimental allergic neuritis induced by sensitization with galactocerebroside. Science204, 1103–1106 (1979b)Google Scholar
  18. Trapp, B. D., McIntyre, L. J., Quarles, R. H., Sternberger, N. H., Webster, H. D.: Immunocytochemical localization of rat peripheral nervous system myelin proteins: P2 protein is not a component of all peripheral nervous system myelin sheaths. Proc. Natl. Acad. Sci. USA76, 3552–3556 (1979)Google Scholar
  19. Uyemura, K., Tobari, C., Hirano, S., Tsukada, Y.: Comparative studies on the myelin proteins of bovine peripheral nerve and spinal cord. J. Neurochem.19, 2607–2614 (1972)Google Scholar
  20. Waksman, B. H., Adams, R. D.: Allergic neuritis: an experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvants. J. Exp. Med.102, 213–236 (1955)Google Scholar
  21. Yonezawa, T., Ishihara, Y., Matsuyama, H.: Studies on experimental allergic peripheral neuritis. J. Neuropathol. Exp. Neurol.27, 453–463 (1968)Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • A. F. Hahn
    • 1
  • J. J. Gilbert
    • 1
  • T. E. Feasby
    • 2
  1. 1.Department of Clinical Neurological Sciences and Department of PathologyVictoria HospitalLondonCanada
  2. 2.Department of Clinical Neurological SciencesUniversity HospitalLondonCanada

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