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Acta Neuropathologica

, Volume 49, Issue 3, pp 169–176 | Cite as

Passive transfer of demyelination by experimental allergic neuritis serum

  • A. F. Hahn
  • J. J. Gilbert
  • T. E. Feasby
Original Works

Summary

Serum from rabbits with experimental allergic neuritis (FAN) when injected into rat sciatic nerves produced rapidly evolving demyelination followed by remyelination. Myelinating and non-myelinating Schwann cells as well as myelin itself were damaged by 15 min after injection. Myelin degradation was well advanced prior to involvement by macrophages at 12 h. The demyelinating factor was myelin-specific and complement-dependent. The evidence suggests that the FAN antigen may reside in Schwann cell membranes as well as in myelin.

Key words

Experimental allergic neuritis Demvelination Humoral immunity Myelin Schwann cell 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • A. F. Hahn
    • 1
  • J. J. Gilbert
    • 1
  • T. E. Feasby
    • 2
  1. 1.Department of Clinical Neurological Sciences and Department of PathologyVictoria HospitalLondonCanada
  2. 2.Department of Clinical Neurological SciencesUniversity HospitalLondonCanada

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