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Complexation of ephedrine withβ-cyclodextrin: An NMR spectroscopy study

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Abstract

This study focuses on the inclusion complex of ephedrine with β-CD. The association of β-CD and ephedrine has been examined using1H NMR and circular dichroism. The systematic shifts of the proton resonances of the phenyl moiety of ephedrine and that of the protons located inside the β-CD cavity, provide evidence of intracavity inclusion. Two-dimensional ROESY show preferential localization of ephedrine in close proximity with protons located inside the β-CD cavity. The systematic variation of circular dichroism spectra with increasing concentration of β-CD is used to estimate the apparent formation constant.

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Authors and Affiliations

  1. Department of Chemistry, Emory University, 30322, Atlanta, Georgia, USA

    Thilivhali T. Ndou, Srinivasan Mukundan Jr. & Isiah M. Warner

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  1. Thilivhali T. Ndou
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  2. Srinivasan Mukundan Jr.
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  3. Isiah M. Warner
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Emory University School of Medicine, Atlanta, GA 30322, U.S.A.

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Ndou, T.T., Mukundan, S. & Warner, I.M. Complexation of ephedrine withβ-cyclodextrin: An NMR spectroscopy study. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry 15, 9–25 (1993). https://doi.org/10.1007/BF00706470

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  • DOI: https://doi.org/10.1007/BF00706470

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