Acta Neuropathologica

, Volume 52, Issue 3, pp 239–242 | Cite as

Creutzfeldt-Jakob disease with extensive degeneration of white matter

  • Tae Sung Park
  • George M. Kleinman
  • Edward P. Richardson
Short Original Communications


Degeneration of the white matter is uncommon in Creutzfeldt-Jakob disease (CJD), and when it occurs is usually mild, and limited in distribution. In the case of a 77-year-old woman with CJD lasting 1 year, there was extensive degeneration of cerebral white matter in addition to severe loss of neurons and hypertrophic astrogliosis in cortex and striatum. The extent and severity of white matter lesions makes the case unusual.

Key words

Creutzfeldt-Jakob disease Spongiform encephalopathy White-matter degeneration 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Tae Sung Park
    • 1
  • George M. Kleinman
    • 1
  • Edward P. Richardson
    • 2
  1. 1.Charles S. Kubik Laboratory for Neuropathology of the James Homer Wright Pathology LaboratoriesMassachusetts General HospitalBostonUSA
  2. 2.Department of Pathoiogy and Neurology (Neuropathology)Harvard Medical SchoolBostonUSA

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