Acta Neuropathologica

, Volume 52, Issue 3, pp 203–211 | Cite as

Gerstmann-Sträussler-Scheinker's disease

Electron-microscopic observations on a brain biopsy
  • W. Schlote
  • J. W. Boellaard
  • F. Schumm
  • M. Stöhr
Original Works

Summary

Light and electron microscopic observations are reported on a brain biopsy of a man of 59 with a rare familial disease of the CNS and a 5-year clinical course. Electron micrographs of the frontal biopsy reveal plaque-like deposits composed of amyloid cores, often multicentric in the cortex and subcortical white matter. They are localized between enlarged astrocytic processes. In the neuropil they are sometimes associated with abnormal neuritic processes, in the white matter with processes of fibrous astroglia and basement membranes. There are no signs of primary neuritic or synaptic involvement in the plaque formation which is more obviously associated with altered astrocytic processes. Moreover, degenerative alterations in the cortical vessels and slight astroglial spongiform changes as well as oligodendroglial proliferation can be found. Plaques are considered to be mainly of the kuru type; the relationship with transmissible spongiform encephalopathies is discussed.

Key words

Dementia Plaques Kuru Spongiform encephalopathies 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • W. Schlote
    • 1
  • J. W. Boellaard
    • 2
  • F. Schumm
    • 3
  • M. Stöhr
    • 3
  1. 1.Abt. für submikroskopische Pathologie und NeuropathologieTübingenGermany
  2. 2.Institut für Hirnforschung der Universität TübingenTübingenGermany
  3. 3.Neurologische Klinik der Universität TübingenTübingenGermany

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