Summary
Although it is accepted that the different components of germ cell tumours (GCT) imitate the embryonic and extraembryonic structures in early development, various tumour patterns remain to be interpreted in histogenetic terms. In particular, some patterns of embryonal carcinoma (EC) and yolk sac tumour (YST) have not been given a convincing histogenetic explanation. Combined morphological and immunohistochemical studies of GCT in addition to a three-dimensional analysis permit correlations between certain tumour patterns and normal embryonic and extraembryonic structures to be made. The various tumour patterns which reflect various stages of differentiation or maturation of cells and tissues of the normal conceptus may also be placed in chronological order with regard to embryogenesis. On the basis of such considerations a nomenclature using the embryological terms for the various tumour components may be considered, although not recommended as a new system of classification.
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Abbreviations
- AFP :
-
Alpha-fetoprotein
- CC :
-
Choriocarcinoma
- CIS :
-
Carcinoma in situ
- EC :
-
Embryonal carcinoma
- ESS :
-
Endodermal sinus structure
- EST :
-
Endodermal sinus tumour
- GCT :
-
Germ cell tumour
- HCG :
-
Human chorionic gonadotropin
- PES :
-
Pseudoendodermal sinus structure
- STLC :
-
Syncytiotrophoblast-like cell
- T :
-
Teratoma
- YST :
-
Yolk sac tumour
- IP :
-
Immunoperoxidase technique
- H :
-
Hematoxylin
- H & E :
-
Hematoxylin and eosin
References
Duval M (1891) Le placenta des rongeurs. J Anat Physiol (Paris) 27:24, 344, 515
Clausen PP, Thomsen P (1978) Demonstration of hepatitis B surface antigen in liver tissue. A comparative investigation of immunoperoxidase and orcein staining on identical sections of formalin fixed, parraffin embedded tissue. Acta Pathol Microbiol Scand Sect A 86:383–388
Dateca Study Group (1978) The Danish Testicular Carcinoma Project (DATECA). Scand J Immunol 8 (suppl 8):147–151
Gaillard JA (1972) Yolk-sac tumour patterns and entoblastic structures in polyembryomas. Acta Pathol Microbiol Scand Sect A 80 (suppl 233):18–25
Gonzalez-Crussi F, Roth LM (1976) The human yolk sac carcinoma. An ultrastructural study. Hum Pathol 7:675–691
Hertig AT, Rock J, Adams EC (1956) A description of 34 human ova with the first 17 days of development. Am J Anat 98:435–493
Hesseldahl H, Larsen JF (1969) Ultrastructure of human yolk sac: Endoderm, mesenchyme, tubules and mesothelium. Am J Anat 126:315–336
Heuser CH, Rock J, Hertig AT (1945) Two human embryos showing early stages of the definitive yolk sac. Contribut Embryol 201:37–99
Jacobsen GK, Jacobsen M (1983) Alåha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) in testicular germ cell tumours. Acta Pathol Microbiol Immunol Scand Sect A 91:165–176
Jacobsen GK, Jacobsen M (1983) Immunohistochemical demonstration of haemoglobin F (HbF) in testicular germ cell tumours. Oncodevelop Biol Med 4:C45-C51
Jacobsen GK, Jacobsen M (1983) Possible liver cell differentiation in testicular germ cell tumours. Histopathology 7:537–548
Jacobsen GK, Jacobsen M, Henriksen OB (1981) An immunohistochemical study of a series of plasma proteins in the early human conceptus. Oncodevelop Biol Med 2:399–410
Langman J (1976) Medical embryology. Third Edition. The Williams and Wilkins Company, Baltimore
Marin-Padilla M (1968) Histopathology of the embryonal carcinoma of the testis. Arch Pathol 85:614–622
Mark GJ, Hedinger C (1965) Changes in remaining tumor-free testicular tissues in cases of seminoma and teratoma. Virchows Arch [Pathol Anat] 340:84–92
Mostofi FK (1977) International histological classification of tumours: No 16. Histological typing of testis tumours. WHO, Geneva
Mukai K, Rosai J (1980) Applications of immunoperoxidase techniques in surgical pathology. In: Fenoglio CM, Wolff M (eds) Progress in surgical pathology, 1st ed vol 1. Masson, New York, pp 25–49
Okamoto T (1983) Comparative morphology of endodermal sinus tumour (Teilum) to human yolk sac and a proposal of endodermal cell tumour. Acta Pathol Jpn 33 (1):1–14
Peyron A (1941) Sur les caracteres morphologiques fondamentaux et les variations secondaires des bouton embryonnaires dans la parthénogénese polyembryonique du testicule. CR Soc Biol (Paris) 135:281–284
Pugh RCB, Cameron KM (1976) Teratoma. In: Pathology of the testis, ed CB Pugh Blackwell Scientific Publications, Oxford, London, Edinburgh, Melbourne
Skakkebæk NE (1975) Atypical germ cells in the adjacent “normal” tissue of testicular tumours. Acta Pathol Microbiol Scand Sect A 83:127–130
Skakkebæk NE, Berthelsen JG (1981) Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory. Inter J Androl (Suppl 4):26–34
Takeda A, Ishizuka T, Goto T, Goto S, Ohta M, Tomoda Y, Hoshino M (1982) Polyembryoma of ovary producing alphafetoprotein and HCG: Immunoperoxidase and electron microscopic study. Cancer 49:1878–1889
Teilum G (1950) “Mesonephroma ovarii” (Schiller); extraembryonic mesoblastoma of germ cell origin in ovary and testis. Acta Pathol Microbiol Scand 27:249–261
Teilum G (1959) Endodermal sinus tumours of the ovary and testis. Comparative morphogenesis of the so-called “mesonephroma ovarii” (Schiller) and extraembryonic (yolk sac allantoic) structures of the rat's placenta. Cancer 12:1092–1105
Teilum G (1976) Special tumors of ovary and testis and related extragonadal lesions. Comparative pathology and histological identification. 2nd ed Munksgaard, Copenhagen and JP Lippincott Co, Philadelphia
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Jacobsen, G.K. Histogenetic considerations concerning germ cell tumours. Vichows Archiv A Pathol Anat 408, 509–525 (1986). https://doi.org/10.1007/BF00705305
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DOI: https://doi.org/10.1007/BF00705305