Abstract
The on-line calculated specific rates of growth, substrate consumption and product formation were used to diagnose microbial activities during a lactic acid fermentation. The specific rates were calculated from on-line measured cell mass, and substrate and product concentrations. The specific rates were more sensitive indicators of slight changes in fermentation conditions than such monitored data as cell mass or product concentrations.
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Abbreviations
- μ 1/h:
-
specific rate of cell growth
- π 1/h:
-
specific rate of substrate consumption
- ρ 1/h:
-
specific rate of product formation
- μ * :
-
dimensionless specific rate of cell growth
- ν * :
-
dimensionless specific rate of substrate consumption
- π * :
-
dimensionless specific rate of product formation
- μ max 1/h:
-
maximum specific rate of cell growth
- ν max 1/h:
-
maximum specific rate of substrate consumption
- π max 1/h:
-
maximum specific rate of product formation
- X g/l:
-
cell mass concentration
- S g/l:
-
substrate concentration
- S * :
-
dimensionless substrate concentration
- S 0 g/l:
-
initial substrate concentration
- P g/l:
-
product concentration
References
Endo, I.; Asama, H.; Nagamune. T.: A database system and an expert system for realizing factory automation in the bioindustries. In: A. Fiechter, H. Okada, R. D. Tanner (Eds.): Bioproducts and Bioprocesses, pp. 337–345. Heidelberg: Springer-Verlag Berlin 1989
Endo, I.; Nagamune, T.: A database system for fermentation processes, Biopr. Eng. 2 (1987) 111–114
Constantine, E.; Hansen, T.: Antigenic analysis of Lactobacillus acidophilus. J. Inf. Dis., 110 (1962) 258–267
Endo, I.; Nagamune, T.; Inoue, I.: Application of Kaiman filter to automatic monitoring system of microbial physiological activities, Ann. New York Acad. Sci. 413 (1983) 228–230.
Nagamune, T.; Endo, I.; Higuchi, H.; Inoue, I.: Optimal ethanol fermentation obtained by successive addition of glucose, Adv. Biotechnol. 2 (1981) 207–212
Halme, A.: Expert system approach to recognize the state of fermentation and to diagnose faults in bioreactors. In: Fish, N. M.; Fox, R. I.; Thornhill, N. F. (Eds.): Computer applications in fermentation technology, pp. 159–169, London: Elsevier Science Publishers 1989
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Pokkinen, M., Bustamante, Z.R.F., Asama, H. et al. Diagnosing lactic acid fermentation based on specific rates of growth, substrate consumption and product formation. Bioprocess Engineering 7, 319–323 (1992). https://doi.org/10.1007/BF00705162
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DOI: https://doi.org/10.1007/BF00705162