Abstract
Complement activation induced by segmented polyurethane and polyurethaneurea was studied. The polymers were synthesized from ABA-type triblock copolyether as a prepolymer, where A represents poly (ethylene oxide) (PEO) and B represents poly (tetramethylene oxide). The PEO contents in the triblock copolyethers were 0, 31 and 62 mol%. The whole complement in serum was activated via the classical and the alternative pathways. The contribution of the fourth complement component (i.e. the classical pathway) became larger with increasing PEO content in the polymers, due to the increased hydrophilicity of the polymer surface. The activation of the alternative pathway was affected by the concentration of NH groups and the degree of swelling of the polymer.
Similar content being viewed by others
References
Y. MITO, A. NISHIMURA, A. SUMIYOSHI, M. KAWAI, Y. NOSE, Y. KAWAMURA and C. YOSHIMOTO,Sogoigaku (General Medicine) 17 (1960) 538 (in Japanese).
P. R. CRADDOCK, J. FEHR, A. P. DALMASSO, K. L. BRIGHAM and H. S. JACOB,J. Clin. Invest. 59 (1977) 879.
P. ALJAMA, P. A. E. BIRD, M. K. WARD, T. G. FEEST, W. WALTER, H. TANBOGA, M. SUSSMAN and D. N. S. KERR,Dialysis Transplant Neurol. 15 (1978) 144.
D. E. CHENOWETH, A. K. CHEUNG and L. W. HENDERSON,Kidney Int. 24 (1983) 764.
D. E. CHENOWETH,Artif. Organs 8 (1984) 281.
A. MAHIOUT, H. MEINHOLD, M. KESSEL, H. SCHULZE and U. BAURMEISTER, ibid.11 (1987) 149.
M. S. PAYNE and T. A. HORBETT,J. Biomed. Mater. Res. 21 (1987) 843.
M. P. CARRENO, D. LABARRE, M. JOZEFOWICZ and M. D. KAZATCHKINE,Mol. Immunol. 25 (1988) 165.
T. E. HUGLI and D. E. CHENOWETH, in “Immunoassays: Clinical Laboratory Techniques for the 1980s”, edited by R. Nakamura, W. R. Dito and E. S. Tucker (Freeman, New York, 1980) p. 433.
B. CREPON, F. MAILLET, M. D. KAZATCHKINE and J. JOZEFONVICZ,Biomater. 8 (1987) 248.
T. MATSUDA, H. IWATA, H. TAKANO, T. AKUTSU, T. KISHIMOTO, S. YAMAGAMI and M. MAEKAWA,Jpn. J. Artif. Organs 17 (1988) 515.
A. NAKAO, H. TAKAGI and S. NAGAOKA, ibid.17 (1988) 574.
K. B. M. REID and R. R. PORTER,Ann. Rev. Biochem. 50 (1981) 433.
S. YOSHIKAWA, H. FUKUMURA, Y. AKAGAKI and S. INAI, in “Advances in Biomaterials”, Vol. 8, “Implant Materials in Biofunction”, edited by C. de Putter, G. L. de Lange, K. de Groot and A. J. C. Lee (Elsevier Science, Amsterdam, 1988) p. 187.
T. MATSUDA, M. NIINOBE and H. IWATA,Jpn J. Artif. Organs 16 (1987) 1045.
H. FUKUMURA, K. HAYASHI, S. YOSHIKAWA, M. MIYA, N. YAMAMOTO and I. YAMASHITA,Biomater. 8 (1987) 74.
T. MATSUDA, K. IMACHI and T. AKUTSU,Jpn J. Artif. Organs 18 (1989) 114.
K. HAYASHI, H. FUKUMURA and N. YAMAMOTO,J. Biomed. Mater. Res., in press.
J. W. BORETOS and W. S. PIERCE, ibid.,2 (1968) 121.
W. MECKEL, W. GOYERT and W. WIEDER, in “Thermoplastic Elastomers”, edited by N. R. Legge, G. Holden and H. E. Schroeder (Hanser, Munich, Vienna, New York, 1987) p. 13.
J. W. BORETOS, W. S. PIERCE, R. E. BAIER, A. F. LEROY and H. J. DONACHY,J. Biomed. Mater. Res. 9 (1975) 327.
D. J. LYMAN, B. KUNTSON, B. MCNEILL and K. SHIBATANI,Trans. Amer. Soc. Artif. Intern. Organs 21 (1975) 49.
D. J. HARROP, in “Developments in Rubber Technology-3”, edited by A. Whelan and K. S. Lee (Applied Science, London, New York, 1982) Ch. 5.
D. E. GREGONIS and J. D. ANDRADE, in “Surface and Interfacial Aspects of Biomedical Polymers”, Vol. 1, edited by J. D. Andrade (Plenum Press, New York, 1985) Ch. 3.
H. E. KAMBIC, S. MURABAYASHI and Y. NOSE,Chem. Engng News 14 April (1986) p. 30.
N. YAMAMOTO, I. YAMASHITA, K. HAYASHI and K. TANAKA,Seitaizairyou (Biomaterials) 2 (1984) 99, in Japanese.
R. J. ZDRAHALA, D. D. SOLOMON, D. J. LENTZ and C. W. McGARY Jr, in “Advances in Biomaterials” Vol. 7, “Biomaterials and Clinical Applications”, edited by A. Pizzoferrato, P. G. Marchetti, A. Ravaglioli and A. J. C. Lee. (Elsevier Science, Amsterdam, 1987) p. 621.
D. K. PARK, T. OKANO, C. NOJIRI and S. W. KIM,J. Biomed. Mater. Res. 22 (1988) 977.
D. K. HAN, S. Y. JEONG and Y. H. KIM, ibid.23 (1989) 211.
S. Q. LIU, Y. ITO and Y. IMANISHI,J. Biomater. Sci. Polym. Ed. 1 (1990) 111.
Y. IKEDA, S. KOHJIYA and S. YAMASHITA,Rubber World 200 (1989) 21.
S. KOHJIYA, S. TAKESAKO, Y. IKEDA and S. YAMASHITA,Polym. Bull. 23 (1990) 299.
Y. IKEDA, S. TAKESAKO, S. KOHJIYA and S. YAMASHITA,Biomater. 8 (1990) 553.
Y. IKEDA, S. KOHJIYA, S. YAMASHITA, N. YAMAMOTO, K. HAYASHI and I. YAMASHITA,Nippon Kagaku Kaishi (J. Chem. Soc. Jpn) (1986) 699, in Japanese.
S. KOHJIYA, Y. IKEDA and S. YAMASHITA, in “Polyurethanes in Biomedical Engineering II”, edited by H. Plank, I. Syre, M. Douner and G. Egbers (Elsevier Science, Amsterdam, 1987) p. 183.
Y. IKEDA, S. KOHJIYA, S. YAMASHITA, H. FUKUMURA and S. YOSHIKAWA,Polymer J. 20 (1988) 273.
Y. IKEDA, S. KOHJIYA, S. YAMASHITA, H. HAYASHI and T. OKUNO,Nihon Reoroji Gakkaishi (J. Soc. Rheol. Jpn) 18 (1990) 12, in Japanese.
M. M. MAYER, in “Experimental Immunochemistry”, 2nd edn, edited by E. A. Kabat and M. M. Mayer (Thomas, Springfield, IL 1961) p. 133.
T. A. GAITHER, D. W. ALLING and M. M. FRANK,J. Immunol. 113 (1974) 574.
N. TAMURA, “Hotaigaku (Complement)”, edited by S. Inai, K. Inoue and N. Tamura (Ishiyakushuppan, Tokyo, 1987) p. 8.
K. ISHIZAKI,Progr. Allergy 7 (1963) 32.
T. UCHIDA, S. HOSAKA and Y. MURAO,Biomater. 5 (1984) 281.
S. J. VAN OSS, C. F. GILLMAN and A. W. NEWMAN, in “Phagocytic Engulfmene and Adhesiveness as Cellular Surface Phenomena” (Marcel Dekker, New York, 1975).
M. OKANO, S. NISHIYAMA, K. SHINOHARA, T. AKAIKE and Y. SAKURAI,Koubunshi Ronbunshu (J. Polym. Soc. Jpn) 36 (1979) 209, in Japanese.
S. K. A. LAW, T. M. MINICH and R. P. LEVINE,Biochem. 20 (1981) 7457.
C. KIYOTAKI,Naika (Intern. Med.) 42 (1978) 346, in Japanese.
D. J. LYMAN, L. C. METCALF, D. ALBO, Jr., K. F. RICHARDS and J. LAMB,Trans. Amer. Soc. Artif. Intern. Organs 20B (1974) 474.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ikeda, Y., Kohjiya, S., Yamashita, S. et al. Activation of complement in human serum by polyurethane having PEO-PTMO-PEO as soft segment. J Mater Sci: Mater Med 2, 110–117 (1991). https://doi.org/10.1007/BF00703469
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00703469