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Study of diffusional properties of silicone matrices for drug bioavailability modulation

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Abstract

Modified silicone elastomers were synthesized by grafting an organic pendent segment (allylglycidylether) along polydimethylsiloxane chains. The effects of the degree of grafting were evaluated with respect to drug solubility, diffusivity and elastomer properties. It was found that this elastomer modification led to a high increase in solubility for a lipophilic steroid (progesterone) and a more hydrophilic drug (metronidazole). Drug diffusivities were not highly reduced; permeability and release properties of these modified silicone networks could also be widely improved not only for steroids but also for more hydrophilic drugs.

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References

  1. T. J. ROSEMAN, in “Controlled release technologies: methods, theory and applications”, Vol. 1 (CRC, Boca Raton, FL, 1980) Ch. 2.

    Google Scholar 

  2. L. C. CLAUSS and E. BAFFERT,Lyon Pharm. 38(3) (1987) 101.

    Google Scholar 

  3. S. BRALEY,J. Macromol. Sci. Chem. A4 (1970) 529.

    Google Scholar 

  4. P. J. DZIUK and B. COOK,Endocrinology 78 (1966) 208.

    Google Scholar 

  5. F. A. KINCL, G. BENAGIANO and I. ANGEE,Steroids 11 (1968) 673.

    Google Scholar 

  6. T. J. ROSEMAN,J. Pharm. Sci. 61(1) (1972) 46.

    Google Scholar 

  7. M. M. GHANNAM, K. TOJO and Y. W. CHIEN,Drug Dev. Ind. Pharm. 12 (1986) 303.

    Google Scholar 

  8. Y. SUN, K. TOJO and Y. W. CHIEN, ibid.12 (1986) 327.

    Google Scholar 

  9. A. ETIENNE,S.T.P. Pharma. 6 (1990) 33.

    Google Scholar 

  10. J. W. McGINITY, L. A. HUNKE and A. B. COMBS,J. Pharm. Sci. 68 (1979) 662.

    Google Scholar 

  11. W. R. PFISTER, R. P. SWEET, M. E. WEAVER and P. A. WALTERS, in “Proceedings of the International Symposium on Controlled Release of Bioactive Materials12 (1985) p. 145.

  12. S. FRIEDMAN, S. S. KOIDE and F. A. KINCL,Steroids 15 (1970) 679.

    Google Scholar 

  13. C. L. LEE, K. L. ULMAN and K. R. LARSON,Drug Dev. Ind. Pharm. 12 (1986) 349.

    Google Scholar 

  14. ——12 (1986) 369.

    Google Scholar 

  15. K. L. ULMAN, G. A. GORNOWICZ, K. R. LARSON and C. L. LEE,J. Controlled Release 10 (1989) 251.

    Google Scholar 

  16. K. L. ULMAN, K. R. LARSON, C. L. LEE and K. TOJO, ibid.10 (1989) 261.

    Google Scholar 

  17. Fr. Pat. 2629 089 (1988).

  18. Eur. Pat. 383 698 (1989).

  19. G. COUARRAZE, B. LECLERC, G. CONRATH and F. FALSON-RIEG,C.R. Acad. Sci. Paris 307 (II) (1988) 329.

    Google Scholar 

  20. G. CONRATH, B. LECLERC, F. FALSON-RIEG, J. P. DEVISSAGUET and G. COUARRAZE,J. Controlled Release 9 (1989) 159.

    Google Scholar 

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Author notes

  1. H. Porte

    Present address: Flamel Technologies, 69693, Vénissieux, France

Authors and Affiliations

  1. Laboratoire de Physique Pharmaceutique, U.R.A. C.N.R.S. 1218, Université Paris-Sud, 92296, Châtenay-Malabry Cedex, France

    J. C. Moreau, B. Leclerc, J. Mazan & G. Couarraze

  2. Rhône-Poulenc C.R.C., B.P. 62, 69192, Saint-Fons Cedex, France

    G. Torrès & H. Porte

Authors
  1. J. C. Moreau
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  2. B. Leclerc
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  3. J. Mazan
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  4. G. Couarraze
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  5. G. Torrès
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  6. H. Porte
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Moreau, J.C., Leclerc, B., Mazan, J. et al. Study of diffusional properties of silicone matrices for drug bioavailability modulation. J Mater Sci: Mater Med 2, 243–247 (1991). https://doi.org/10.1007/BF00703379

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  • DOI: https://doi.org/10.1007/BF00703379

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