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Interactions of biospecific sorbents with physiologically active substances

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Abstract

The synthesis and application of hydrogel biospecific sorbents with immobilized physiologically active substances for creation of bio- and blood-compatible polymeric materials are given and discussed. The chemical nature and structure of affinic ligand, its availability and distribution in the matrix determine the action efficiency of these sorbents. A high blood-compatibility of polymers can be reached by chemical modification with several physiologically active substances acting at the different steps of thromboformation. The complex biotissue chemical modification permits the reduction of calcium and phosphorus accumulation inin vivo experiments by 10–100 times, compared with the control.

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Authors and Affiliations

  1. Polymer Chemistry Department of Moscow State University, National Research Center of Surgery, Moscow, USSR

    L. D. Uzhinova, N. A. Platé & S. M. Krasovskaja

Authors
  1. L. D. Uzhinova
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  2. N. A. Platé
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  3. S. M. Krasovskaja
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Uzhinova, L.D., Platé, N.A. & Krasovskaja, S.M. Interactions of biospecific sorbents with physiologically active substances. J Mater Sci: Mater Med 2, 189–192 (1991). https://doi.org/10.1007/BF00703367

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  • DOI: https://doi.org/10.1007/BF00703367

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