Dense core vesicles around the Lewy body in incidental Parkinson's disease: an electron microscopic study
- 105 Downloads
In a case of Lewy body disease incidentally found at autopsy, numerous dense core vesicles, 80–200 nm in diameter, were seen in the neuronal perikarya of the locus caeruleus. They were particularly numerous in the vicinity of the Lewy bodies. The change seems to occur at the early stage of Lewy body production and may represent an additional morphologic clue to abnormal catecholamine metabolism in Parkinson's disease.
Key wordsParkinson's disease Lewy body Dense core vesicles Electron microscopy
Unable to display preview. Download preview PDF.
- Duffy, P. E., Tennyson, V. M.: Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus caeruleus in Parkinson's disease. J. Neuropath. Exp. Neurol.24, 398–414 (1965)Google Scholar
- Forno, L. S.: Concentric hyalin intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases): Relationship to Parkinsonism. J. Am. Geriatr. Soc.17, 557–575 (1969)Google Scholar
- Forno, L. S., Alvord E. C. Jr.: The pathology of parkinsonism. In: Recent advances in Parkinson's disease. Contemporary Neurology Series, No. 8 (eds., F. H. McDowell and C. H. Markham), pp. 120–130. Philadelphia: F. A. Davis 1971Google Scholar
- Forno, L. S., Norville, R. L.: Ultrastructure of Lewy bodies in the stellate ganglion. Acta Neuropath. (Berl.)34, 183–197 (1976)Google Scholar
- Greenfield, J. G., Bosonquet, F. D.: The brain-stem lesions in Parkinsonism. J. Neurol. Neurosurg. Psychiat.16, 213–226 (1953)Google Scholar
- den Hartog Jager, W. A., Bethlem, J.: The distribution of Lewy bodies in the central and autonomic nervous system in idiopathic paralysis agitans. J. Neurol. Neurosurg. Psychiat.23, 283–290 (1960)Google Scholar
- Lewy, F. H.: Paralysis agitans. I. Pathologische Anatomie. In: Handbuch der Neurologie (ed. M. Lewandowsky), pp. 920–933, Berlin: J. Springer 1912Google Scholar
- Lipkin L. E.: Cytoplasmic inclusions in ganglion cells associated with Parkinsonian states A neurocellular change studied in 53 cases and 206 controls. Amer. J. Path.35, 1117–1133 (1959)Google Scholar
- Roy, S., Wolman, L.: Ultrastructural observations in Parkinsonism. J. Path.99, 39–44 (1969)Google Scholar
- Schochet, S. S.: Neuronal inclusions. In: The structure and function of nervous tissue IV (ed. G. H. Bourne). pp. 129–177. New York-London: Academic Press 1972Google Scholar
- Thapedi, I. M., Ashenhurst, E. M., Rozdilsky, B.: Shy-Drager syndrome: Report of an autopsied case. Neurology.21, 26–32 (1971)Google Scholar