Acta Neuropathologica

, Volume 39, Issue 2, pp 173–175 | Cite as

Dense core vesicles around the Lewy body in incidental Parkinson's disease: an electron microscopic study

  • Itaru Watanabe
  • Eva Vachal
  • Tatsuo Tomita
Short Original Communication

Summary

In a case of Lewy body disease incidentally found at autopsy, numerous dense core vesicles, 80–200 nm in diameter, were seen in the neuronal perikarya of the locus caeruleus. They were particularly numerous in the vicinity of the Lewy bodies. The change seems to occur at the early stage of Lewy body production and may represent an additional morphologic clue to abnormal catecholamine metabolism in Parkinson's disease.

Key words

Parkinson's disease Lewy body Dense core vesicles Electron microscopy 

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References

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Itaru Watanabe
    • 1
    • 2
  • Eva Vachal
    • 1
    • 2
  • Tatsuo Tomita
    • 1
    • 2
  1. 1.Veterans Administration HospitalKansas CityUSA
  2. 2.Department of Pathology and OncologyUniversity of Kansas College of Medical Sciences and HospitalKansas CityUSA

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