Clofibrate-induced myopathy in the rat
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Rats were given daily injections of 0.2 or 0.5 g/kg chlorophenoxyisobutyrate (clofibrate) for 9 to 46 days. Lower leg muscles were studied with light and electron microscopy.
Daily treatment with 0.5 g/kg of the drug for 26–46 days caused myopathic changes.
Key wordsClofibrate Striated muscle Histochemistry Electron microscopy Experimental animal
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