Acta Neuropathologica

, Volume 39, Issue 2, pp 135–138 | Cite as

Clofibrate-induced myopathy in the rat

  • Heikki Teräväinen
  • Andreo Larsen
  • Matti Hillbom
Original Investigations


Rats were given daily injections of 0.2 or 0.5 g/kg chlorophenoxyisobutyrate (clofibrate) for 9 to 46 days. Lower leg muscles were studied with light and electron microscopy.

Daily treatment with 0.5 g/kg of the drug for 26–46 days caused myopathic changes.

Key words

Clofibrate Striated muscle Histochemistry Electron microscopy Experimental animal 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Heikki Teräväinen
    • 1
  • Andreo Larsen
    • 1
  • Matti Hillbom
    • 1
  1. 1.Department of NeurologyUniversity of HelsinkiHelsinki 29Finland

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