Russian Chemical Bulletin

, Volume 44, Issue 3, pp 547–550 | Cite as

Some derivatives of pregna-D6′-pentaranes as possible antagonists of progesterone

  • I. S. Levina
  • G. V. Nikitina
  • L. E. Kulikova
  • A. V. Kamernitzky
Chemistry of Natural Compounds and Bioorganic Chemistry


Some derivatives of progestins of the pregna-D6′-pentarane series have been obtained and examined for their possible hormonal and antihormonal activity in the Clauberg-McPhail assay as well as in the pregnancy maintenance test in ovariectomized rabbits. 16α, 17α-Cyclohexanoprogesterones of the 19-methyl and 19-nor series (1–4) saturated in ring A, which are inactive as progestins, exhibited a remarkable antiprogesterone effect. They decreased the McPhail index under combined administration with progesterone in a dose-dependable manner and completely inhibited the action of the latter in the pregnancy maintenance test.

Key words

pentarane progestin Clauberg-McPhail assay antihormonal action progesterone 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • I. S. Levina
    • 1
  • G. V. Nikitina
    • 1
  • L. E. Kulikova
    • 1
  • A. V. Kamernitzky
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

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