Advertisement

Russian Chemical Bulletin

, Volume 44, Issue 3, pp 547–550 | Cite as

Some derivatives of pregna-D6′-pentaranes as possible antagonists of progesterone

  • I. S. Levina
  • G. V. Nikitina
  • L. E. Kulikova
  • A. V. Kamernitzky
Chemistry of Natural Compounds and Bioorganic Chemistry

Abstract

Some derivatives of progestins of the pregna-D6′-pentarane series have been obtained and examined for their possible hormonal and antihormonal activity in the Clauberg-McPhail assay as well as in the pregnancy maintenance test in ovariectomized rabbits. 16α, 17α-Cyclohexanoprogesterones of the 19-methyl and 19-nor series (1–4) saturated in ring A, which are inactive as progestins, exhibited a remarkable antiprogesterone effect. They decreased the McPhail index under combined administration with progesterone in a dose-dependable manner and completely inhibited the action of the latter in the pregnancy maintenance test.

Key words

pentarane progestin Clauberg-McPhail assay antihormonal action progesterone 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    I. S. Levina, A. V. Kamernitzky,Khim.-farm. zhurn., 1990,24(10), 31.Google Scholar
  2. 2.
    N. D. Fanchenko, A. V. Kamernitzky, L. S. Minina, I. S. Levina, M. L. Alekseeva, E. A. Novikov, L. E. Kulikova,Bull. exper. biol. med., 1988, No. 6, 679.Google Scholar
  3. 3.
    A. Bhakta, M. Herman, I. S. Levina, and V. K. Moudgil,Mol. Cell. Biochem., 1993,125, 153.Google Scholar
  4. 4.
    A. V. Kamernitzky, I. S. Levina,Khim.-farm. zhurn., 1991,25(10), 4.Google Scholar
  5. 5.
    I. S. Levina, G. V. Nikitina, L. E. Kulikova, and A. V. Kamernitzky,Abstr. IX Int. Congr. Horm. Steroids, Dallas, USA, Sept., 1994, C152.Google Scholar
  6. 6.
    Ger.(East) DD263776;Chem. Abstrs., 1989,111, 195236x.Google Scholar
  7. 7.
    A. V. Kamernitzky, I. S. Levina, L. E. Kulikova, G. V. Nikitina, V. V. Korkhov,Khim.-farm. zhurn., 1990,24(3), 24.Google Scholar
  8. 8.
    Ger.(East) DD263777;Chem. Abstrs., 1989,111, 174532a.Google Scholar
  9. 9.
    I. S. Levina, L. E. Kulikova, A. V. Kamernitzky, B. S. Elyanov, E. M. Gonikberg,Izv. AN SSSR, Ser. khim., 1992, 1622 [Bull. Acad. Sci. USSR, Div. Chem. Sci., 1992,41, 1253 (Engl. Transl.)].Google Scholar
  10. 10.
    A. V. Kamernitzky, I. S. Levina, L. E. Kulikova, V. N. Ignatov, V. V. Korkhov, G. V. Nikitina, and A. I. Terekhina,J. Steroid Biochem., 1982,16, 61.Google Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • I. S. Levina
    • 1
  • G. V. Nikitina
    • 1
  • L. E. Kulikova
    • 1
  • A. V. Kamernitzky
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation

Personalised recommendations