Abstract
Mucins are high molecular weight glycoproteins that are heavily glycosylated with many oligosaccharide side chains linked O-glycosidically to the protein backbone. With the recent application of molecular biological methods, the structures of apomucins and regulation of mucin genes are beginning to be understood. At least nine human mucin genes have been identified to date. Although a complete protein sequence is known for only three human mucins (MUC1, MUC2, and MUC7), common motifs have been identified in many mucins. The pattern of tissue and cell-specific expression of these mucin genes are emerging, suggesting a distinct role for each member of this diverse mucin gene family. In epithelial cancers, many of the phenotypic markers for pre-malignant and malignant cells have been found on the carbohydrate and peptide moieties of mucin glycoproteins. The expression of carbohydrate antigens appears to be due to modification of peripheral carbohydrate structures and the exposure of inner core region carbohydrates. The expression of some of the sialylated carbohydrate antigens appears to correlate with poor prognosis and increased metastatic potential in some cancers. The exposure of peptide backbone structures of mucin glycoproteins in malignancies appears to be due to abnormal glycosylation during biosynthesis. Dysregulation of tissue and cell-specific expression of mucin genes also occurs in epithelial cancers. At present, the role of mucin glycoproteins in various stages of epithelial cell carcinogenesis (including the preneoplastic state and metastasis), in cancer diagnosis and immunotherapy is under investigation.
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References
Allen DC, Connolly NS, Biggart JD (1988)Histopathology 13: 399–411.
Gold DV, Miller F (1978)Cancer Res 38: 3204–11.
Jass JR, Roberton AM (1994)Pathol Int 44: 487–504.
Hakomori SI (1989)Adv Cancer Res 52: 257–331.
Kim YS, Byrd JC (1991) InBiochemical and Molecular Aspect of Selected Cancers, Vol. 1 (Pretlow TG II, Pretlow TP, eds) pp. 277–311, New York: Academic Press.
Kim YS (1993)Eur J Gastroenterol Hepatol 5: 219–25.
Neutra MR, Forstner JF (1987) InPhysiology of the Digestive Tract 2 edn, (Johnson LR, ed) pp. 975–1009. New York: Raven Press.
Strous GF, Dekker J (1992)CRC Crit Rev Biochem Mol Biol 27: 57–92.
Rose MC (1992)Am J Physiol 263: L413–29.
Siddiqui J, Abe M, Hayes D, Shani E, Yunis E, Kufe D (1988)Proc Natl Acad Sci USA 85: 2320–23.
Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani E, Wilson D (1990)J Biol Chem 265: 15286–93.
Wreschner DH, Hareuveni M, Tsarfaty H, Smorodinsky N, Horev J, Zaretsky J, Kotkes P, Weiss M, Lathe R, Dion A, Keydar I (1990)Eur J Biochem 189: 463–73.
Ligtenberg MJL, Vos HL, Gennissen AMC, Hilkens J (1990)J Biol Chem 265: 5573–78.
Lan MS, Batra SK, Qi W, Metzgar RS, Hollingsworth MA (1990)J Biol Chem 265: 15294–99.
Gum JR, Byrd JC, Hicks JW, Toribara NW, Lamport DTA, Kim YS (1989)J Biol Chem 264: 6480–87.
Gum JR, Hicks JW, Swallow DM, Lagace RE, Byrd JC, Lamport DTA, Siddiki B, Kim YS (1990)Biochem Biophys Res Comm 171: 407–15.
Aubert JP, Porchet N, Crepin M, Duterque-Coquillaud M, Vergnes G, Mazzuca M, Debuire B, Pretiprez D, Degand P (1991)Am J Respir Cell Mol Biol 5: 178–85.
Porchet N, Van Cong N, Dufosse J, Audie JP, Guyonnet-Duperat V, Gross MS, Denis C, Degard P, Bernheim A, Aubert JP (1991)Biochem Biophys Res Comm 175: 414–22.
Meerzaman D, Charles P, Daskal E, Polymerophoulos MH, Martin BM, Rose MC (1994)J Biol Chem 269: 12932–39.
Lesuffleur T, Roches F, Hill AS, Lacasa M, Fox M, Swallow DM, Zweibaum A, Real FX (1995)J Biol Chem 270: 13665–73.
Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (1995)Biochem J 305: 211–19.
Toribara NW, Roberton AM, Ho SB, Kuo WL, Hicks JW, Gum E, Gum JR, Byrd JC, Siddiki B, Kim YS (1993)J Biol Chem 268: 5879–85.
Bobek LA, Tsai H, Biesbrock AR, Levine MJ (1993)J Biol Chem 268: 20563–69.
Shankar V, Gilmore MS, Elkins RC, Sachdev GP (1994)Biochem J 300: 295–98.
Bhargava AK, Woitach JT, Davidson EA, Bhavanandan VP (1990)Proc Natl Acad Sci USA 87: 6798–802.
Eckhardt A, Timpte C, Abernathy J, Toumadje A, Johnson WJ, Hill R (1987)J Biol Chem 262: 11339–44.
Spicer AP, Parry G, Patton S, Gendler SJ (1991)J Biol Chem 266: 15099–109.
Gum JR, Hicks JW, Lagace RE, Byrd JC, Toribara NW, Siddiki B, Fearney FJ, Lamport DTA, Kim YS (1991)J Biol Chem 266: 22733–38.
Hoffmann W (1988)J Biol Chem 263: 7686–90.
Hoffmann W, Hauser F (1993)Trends Biochem Sci 18: 239–43.
Swallow DM, Gendler S, Griffiths B, Corney G, Taylor-Papadimitriou J, Bramwell ME (1987)Nature 328: 82–84.
Swallow DM, Gendler S, Griffiths B, Kearney A, Povey S, Sheer D, Palmer RW, Taylor-Papadimitrious J (1987)Ann Hum Genet 51: 289–94.
Hilkens J, Buijs F, Ligtenberg M (1989)Cancer Res 49: 786–93.
Hilkens J, Ligtenberg MJ, Vos HL, Litvinov SV (1992)Trends in Biochem Sci 17: 359–63.
Jentcroft N (1990)Trends Biochem Sci 15: 291–94.
Baeckström D, Zhang K, Asker N, Rüetsch UEM, Hansson GC (1995)J Biol Chem 270: 13688–92.
Chang S-K, Dohrman AF, Basbaum CB, Ho SB, Toribara NW, Gum JR, Kim YS (1994)Gastroenterology 107: 28–36.
Gum JR, Hicks JW, Toribara NW, Rothe EM, Lagace RE, Kim YS (1992)J Biol Chem 267: 21375–83.
Gum JR, Hicks JW, Toribara NW, Siddiki B, Kim YS (1994)J Biol Chem 269: 2440–46.
Fox MF, Lahbib F, Pratt W, Attwood J, Gum JR, Kim YS, Swallow DM (1992)Ann Hum Genet 56: 281–87.
Toribara NW, Gum E, Lau P, Gum JR, Kim YS (1996)Gastroenterology, Abstract: in press.
Kim YS, Gum JR (1995)Gastroenterology 109: 999–1013.
Kindon H, Pothoulakis C, Thim L, Lynch-Devaney K, Podolsky DK (1995)Gastroenterology 109: 516–23.
Audie JP, Janin A, Porchet N, Copin MC, Gosselin B, Aubert JP (1993)J Histochem Cytochem 41: 1479–85.
Ho SB, Roberton AM, Shekels L, Lyftogt CT, Niehans GA, Toribara NW (1995)Gastroenterology 109: 735–47.
de Bolós C, Garrido M, Real FX (1995)Gastroenterology 109: 723–34.
Ligtenberg MJL, Kruijshaar L, Buijs F, Van Meijer M, Litvinov SV, Hilkens J (1992)J Biol Chem 267: 6171–77.
Ohara S, Byrd JC, Gum J, Kim YS (1994)Biochem J 297: 509–16.
Roussel P, Lamblin G, Lhermitte M, Houdret N, Lafitte J, Perini J, Klein A, Scharfman A (1988)Biochemie 70: 1471–82.
Schachter H, Brockhausen I (1992) In:Glycoconjugates, Composition, Structure and Function (Allen HJ, Kisailus EC, eds) pp. 263–332. New York: Marcel Dekker.
Brockhausen I (1995) In:New Comprehensive Biochemistry Vol. 29a. Glycoproteins (Montreuil L, Vliegenthart HFG, Schachter H, eds) pp. 201–59. Amsterdam: Elsevier.
Podolsky DK (1985)J Biol Chem 260: 15510–15.
Podolsky DK (1985)J Biol Chem 260: 8262–71.
Slomiany BL, Zdebska E, Slomiany A (1984)J Biol Chem 259: 2863–69.
Slomiany A, Zdebska E, Slomiany BL (1984)J Biol Chem 259: 14743–49.
Kim YS, Isaacs R (1975)Cancer Res 35: 2092–97.
Shimamoto C, Deshmukh GD, Rigot WL, Boland CR (1989)Biochem Biophys Acta 991: 284–95.
Boland CR, Deshmukh GD (1990)Gastroenterology 98: 1170–77.
Kurosaka A, Nakajima H, Funakoshi I, Matsuyama M, Nagayo T, Yamashina I (1983)J Biol Chem 258: 11594–98.
Kurosaka A, Fukui S, Kitagawa H, Nakada H, Numata Y, Funakoshi I, Kawasaki T, Yamashina I (1987)FEBS Lett 215: 137–39.
Capon C, Laboisse CL, Wieruszeki JM, Maoret JJ, Augeron C, Fournet B (1992)J Biol Chem 267: 19248–57.
Springer GF, Ghazizadeh M, Desai PR, Tegtmeyer H (1995)Cancer Detect Prevent 19: 173–82.
Takahashi HK, Metoki R, Hakomori S (1988)Cancer Res 48: 4361–67.
Longenecker BM, Willans DJ, Maclean GD, Selvaraj S, Suresh MR, Noujaim AA (1987)J Natl Cancer Inst 78: 489–96.
Thor A, Ohuchi N, Szpak C, Johnston W, Schlom J (1986)Cancer Res 46: 3118–24.
Siddiki BB, Huang J, Ho JJL, Byrd JC, Lau E, Yuan M, Kim YS (1993)Int J Cancer 54: 467–74.
Itzkowitz SH, Yuan M, Montgomery CK, Kjeldsen T, Takahashi HK, Bigbee WL, Kim YS (1989)Cancer Res 49: 197–204.
Itzkowitz SH, Bloom EJ, Lau T-S, Kim YS (1992)Gut 33: 518–23.
Johnson V, Schlom J, Paterson A, Bennett J, Magnani J, Colcher D (1986)Cancer Res 46: 850–57.
Samuel J, Noujaim A, MacLean G, Suresh M, Longenecker B (1990)Cancer Res 50: 4801–8.
Nilsson O, Mansson J-E, Lindholm L, Holmgren J, Svennerholm L (1985)FEBS Lett 182: 398–402.
Mansson J-E, Fredman P, Nilsson O, Lindholm L, Holmgren J, Svennerholm L (1985)Biochim Biophys Acta 834: 110–17.
Atkinson BF, Ernst CS, Herlyn M, Steplewski Z, Sears HF, Koprowski H (1982)Cancer Res 42: 4820–23.
Arends JW, Wiggers T, Schutte B, Thijs CT, Verstijen C, Hilgers J (1983)Int J Cancer 32: 289–93.
Chung YS, Ho JJL, Kim YS, Tanaka H, Nakata B, Hiura A, Motoyoshi H, Satake K, Umeyama K (1987)Cancer 60: 1636–43.
Ho JJL, Chung Y, Fujimoto Y, Bi N, Yuan S, Byrd JC, Kim YS (1988)Cancer Res 48: 3924–31.
Metzgar R, Rodriguez N, Finn O, Lan M, Daasch V, Fernsten P (1984)Proc Natl Acad Sci USA 81: 5242–46.
Magnani JL, Steplewski Z, Koprowski H, Ginsburg V (1983)Cancer Res 43: 5489–92.
Itzkowitz SH, Yuan M, Fukushi Y, Lee H, Shi Z, Zurawski V, Jr, Hakomori SI, Kim YS (1988)Cancer Res 48: 3834–42.
Pour PM, Tempero MM, Takasaki H, Uchida E, Takiyama Y, Burnett DA (1988)Cancer Res 48: 5422–26.
Miyake M, Kohno N, Nudelman E, Hakomori S (1989)Cancer Res 49: 5689–95.
Itzkowitz SH, Yuan M, Fukushi Y, Palekar A, Phelps PC, Shamsuddin AM, Trump BF, Hakomori SI, Kim YS (1986)Cancer Res 46: 2627–32.
Yuan M, Itzkowitz SH, Ferrell LD, Fukushi Y, Palekar A, Hakomori SI, Kim YS (1987)J Natl Cancer Inst 78: 479–88.
Kim YS, Yuan M, Itzkowitz SH, Sun Q, Kaizu T, Palekar A, Trump BF, Hakomori S (1986)Cancer Res 46: 5985–92.
Kim YS, Itzkowitz SH, Yuan M, Chung YS, Satake K, Umeyama K, Hakomori SI (1988)Cancer Res 48: 475–82.
Szulman AE (1964)J Exp Med 119: 503–15.
Szulman AE, Marcus DM (1973)Lab Invest 28: 565–74.
Yuan M, Itzkowitz SH, Palekar A, Shamsuddin AM, Phelps PC, Trump BF, Kim YS (1985)Cancer Res 45: 4499–511.
Itzkowitz SH, Yuan M, Ferrell LD, Ratcliffe RM, Chung YS, Satake K, Umeyama K, Jones RT, Kim YS (1987)J Natl Cancer Inst 79: 425–34.
Quaroni A, Weiser MM, Herrera L, Fay D (1989)Immunol Invest 18: 391–404.
Bara J, Gautier R, Daher N, Zaghouani H, Burtin P (1986)Cancer Res 46: 3983–89.
Filipe MI, Barbatis C, Sandey A, Ma J (1988)Hum Pathol 19: 19–26.
Gottlinger HG, Lobo FM, Grimm TW, Riethmuller G, Johnson JP (1988)Cancer Res 48: 2198–203.
Sakurai Y, Hirohashi S, Shimosato Y, Kodaira S, Abe O (1988)Cancer Res 48: 4053–58.
Davis H, Jr, Vz RB, Jr, Klug T (1986)Cancer Res 46: 6143–48.
Paulson JC, Weinstein J, Schauer A (1989)J Biol Chem 264: 10931–34.
Wen DX, Svensson EC, Paulson JC (1992)J Biol Chem 267: 2512–18.
Dall'Olio F, Malagolini N, Stefano G, Minni F, Marrano D, Serafinicessi F (1989)Int J Cancer 44: 434–39.
Yang J-M, Byrd JC, Siddiki BB, Chung Y-S, Okuno M, Sowa M, Kim YS, Matta KL, Brockhausen I (1994)Glycobiology 4: 873–84.
Vavasseur F, Yang J-M, Dole K, Paulsen H, Brockhausen I (1995)Glycobiology 5: 351–57.
King M-J, Chan A, Roe R, Warren F, Dell A, Morris HR, Bartolo CC, Durdey P, Corfield AP (1994)Glycobiology 4: 267–79.
Sugihara K, Jass JR (1986)J Clin Pathol 39: 1088–95.
Hutchins JT, Reading CL, Giavazzi R, Hoaglund J, Jessup JM (1988)Cancer Res 48: 483–89.
Ogata S, Ho I, Chen A, Dubois D, Maklansky J, Singhal A, Hakomori S (1995)Cancer Res 55: 1869–74.
Holmes EH, Hakomori S, Ostrander GK (1987)J Biol Chem 262: 15649–58.
Lowe J, Kukowska-Latallo J, Nair R, Larsen R, Marks R, Macher B, Kelly R, Ernst L (1991)J Biol Chem 266: 17467–77.
Tyrrell D, James P, Rao N, Foxall C, Abbas S, Dasgupta F, Nashed M, Hasegawa A, Kiso M, Asa D, Kidd J, Brandley B (1991)Proc Natl Acad Sci 88: 10372–76.
Nelson RM, Dolich S, Aruffo A, Cecconi O, Bevilacqua MP (1993)J Clin Invest 91: 1157–66.
Majuri M-L, Niemelä R, Tiisala S, Renkonen O, Renkonen R (1995)Int J Cancer 63: 551–59.
Kim YS, Isaacs R, Perdomo J (1974)Proc Natl Acad Sci USA 71: 4869–73.
Itzkowitz SH, Dahiya R, Byrd JC, Kim YS (1990)Gastroenterology 99: 431–42.
Dahiya R, Itzkowitz SH, Byrd JC, Kim YS (1989)Cancer Res 49: 4550–58.
Yamamoto F, Clausin H, White T, Marken J, Hakomori S (1990)Nature (Lond.) 345: 229–33.
David L, Leitao D, Sobrinho-Simoes M, Bennett EP, White T, Mandel U, Dabelsteen E, Clausen H (1993)Cancer Res 53: 5494–500.
Yan PS, Ho SB, Itzkowitz SH, Byrd JC, Siddiqui B, Kim YS (1990)Lab Invest 62: 698–706.
Ho SB, Niehans GA, Lyftogt CT, Yan P-S, Cherwitz DL, Gum ET, Dahiya R, Kim YS (1993)Cancer Res 53: 641–51.
Osaka M, Yonezawa S, Siddiki B, Huang J, Ho JJL, Kim YS, Sato E (1993)Cancer 71: 2191–99.
Girling A, Bartkova J, Burchell J, Gendler S, Gillett C, Taylor-Papadimitriou J (1989)Int J Cancer 43: 1072–75.
Merlo GR, Siddiqui J, Cropp CS, Liscia DS, Lidereau R, Callahan R, Kufe D (1989)Cancer Res 49: 6966–71.
Gendler SJ, Cohen EP, Craston A, Duhig T, Johnstone G, Barnes D (1990)Int J Cancer 45: 431–35.
Hanisch FG, Uhlenbruch G, Dienst C, Stottrop M, Hippaunf E (1985)Eur J Biochem 149: 323–30.
Hull S, Bright K, Carraway K, Abe M, Hayes D, Kufe D (1989)Cancer Commun 1: 262–67.
Brockhausen I, Yang J-M, Burchell J, Whitehouse C, Taylor-Papadimitrious J (1995)Eur J Biochem 233: 607–17.
Ogata S, Uehara H, Chen A, Itzkowitz SH (1992)Cancer Res 52: 5971–78.
Ho SB, Shenkels LL, Toribara NW, Kim YS, Lyftogt CT, Cherwitz DL, Niehans GA (1995)Cancer Res 55: 2681–90.
Balagé C, Gambús G, Carrato C, Porchet N, Aubert J-P, Kim YS, Real FX (1994)Gastroenterology 106: 1054–61.
Hollingsworth MA, Strawhecker JM, Caffrey TC, Mack DR (1994)Int J Cancer 57: 198–203.
Yonezawa S, Nomoto M, Matsukita S, Xing P-X, McKenzie IFC, Hilkens J, Kim YS, Sato E (1995)Cytochem 28: 239–46.
Sanderson SJ, Ewing SL, Shekels LL, Evans MK, Toribara NW, Ho SB (1996)Gastroenterology (abstract): in press.
Yamashita K, Yonezawa S, Tanaka S, Shirahama H, Sakoda K, Imai K, Xing P-X, McKenzie IFC, Hilkens J, Kim YS (1993)Int J Cancer 55: 82–91.
Sasaki M, Nakanuma Y, Terada T, Kim YS (1995)Am J Pathol 147: 574–79.
Lesuffleur T, Porchet N, Aubert J-P, Swallow D, Gum JR, Kim YS, Real FX, Zweibaum A (1993)J Cell Science 106: 771–83.
Kitamura H, Cho M, Gum JR, Lee B-H, Toribara NW, Lesuffleur T, Zweibaum A, Kim YS (1995)Europ J Cancer: in press.
Yogeeswaran G, Salk PL (1981)Science 212: 1514–16.
Dennis J, Waller C, Timpl R, Schirrmacher V (1982)Nature 300: 274–76.
Bresalier RS, Boland CR, Kim YS (1984)Gastroenterology 87: 115–22.
Harvey BE, Toth CA, Wagner HE, Steele GD, Thomas P (1992)Cancer Res 52: 1775–79.
Bresalier RS, Rockwell RW, Dahiya R, Kim YS (1990)Cancer Res 50: 1299–307.
Bresalier RS, Ho SB, Shoeppner HL, Kim YS, Sleisenger MH, Brodt, P, Byrd JC (1995)Gastroenterology: in press.
Hoff SD, Matsushita Y, Ota DM, Cleary KR, Yamori T, Hakomori S, Irimura T (1989)Cancer Res 49: 6883–88.
Kijima-Suda I, Miyamoto Y, Toyoshima S, Itoh M, Osawa T (1986)Cancer Res 46: 858–62.
Kuan S-F, Byrd JC, Basbaum CB, Kim YS (1987)Cancer Res 47: 5715–24.
Bresalier RS, Niv Y, Byrd JC, Duh Q-Y, Toribara NW, Rockwell R, Dahiya R, Kim YS (1991)J Clin Invest 87: 1037–45.
Irimura T, Gonzalez R, Nicolson GL (1981)Cancer Res 41: 3411–18.
Schirrmacher V (1985)Adv Cancer Res 43: 1–73.
Stanford DR, Starkey JR, Magnuson JA (1986)Int J Cancer 37: 435–44.
Dube VE (1987)Cancer Metastasis Rev 6: 541–57.
Bharathan S, Moriarty J, Moody CE, Sherblom AP (1990)Cancer Res 50: 5250–56.
Carraway K, Fregien N, Carraway-3d K, Carraway C (1992)J Cell Sci 103: 299–307.
Sawada T, Ho JJL, Sogabe T, Yoon W-H, Chung Y-S, Sowa M, Kim YS (1993)Biochem Biophys Res Commun 195: 1096–103.
Bevilacqua MP, Nelson RM (1993)J Clin Invest 91: 379–87.
Majuri M-L, Mattila P, Renkonen R (1992)Biochem Biophys Res Commun 182: 1376–82.
Kojima N, Handa K, Newman W, Hakomori S (1992)Biochem Biophys Res Commun 182: 1288–95.
Hareuveni M, Gautier C, Kieny M-P, Wreschner DH, Chambon P, Lathe R (1990)Proc Natl Acad Sci USA 87: 9498–502.
Yuen C-T, Bezouska K, O'Brien J, Stoll M, Lemoine R, Lubineau A, Kiso M, Hasegawa A, Bockovich NJ, Nicolaou KC, Feizi T (1994)J Biol Chem 269: 1595–98.
Mannori G, Crottet P, Cecconi O, Hanasaki K, Aruffo A, Nelson RM, Varki A, Bevilacqua MP (1995)Cancer Res 55: 4425–31.
Huang J, Byrd JC, Yoon W-H, Kim YS (1992)Oncology Res 4: 507–15.
Shogren R, Gerken TA, Jentoft N (1989)Biochemistry 28: 5525–36.
Ligtenberg MJ, Buijs F, Vos HL, Hilkens J (1992)Cancer Res 52: 2318–24.
Nakamori S, Ota DM, Cleary KR, Shirotani K, Irimura T (1994)Gastroenterology 106: 353–61.
Itzkowitz SH, Bloom EJ, Kokal WA, Modin G, Hakomori S, Kim YS (1990)Cancer 66: 1960–66.
Nakamori S, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, Sasaki Y, Kabuto T, Iwanaga T, Matsushita Y, Irimua T (1993)Cancer Res 53: 3632–37.
Satake K, Chung Y-S, Umeyama K, Takeuchi T, Kim YS (1991)Cancer 68: 149–52.
Ho JJL, Chung YS, Yuan M, Henslee J, Kim YS (1992)Int J Cancer 52: 693–700.
Chung Y-S, Nakata B, Sawada T, Yamashita K, Ho JJL, Kim YS, Sowa M (1993)Int J Oncology 2: 921–26.
Ho JJL, Kim YS (1994)Pancreas 9: 674–91.
Brown BA, Comeau RD, Jones PL (1987)Cancer Res 47: 1149–54.
Colcher D, Esteban JM, Carrasquillo JA, Schlom J (1987)Cancer Res 47: 1185–89.
Schlom J, Horan Hand H, Greiner JW (1990)Cancer Res 50(suppl: 820s-7s.
Meredity RF, Khazaeli MB, Plott WE (1992)J Nucl Med 33: 23–29.
Horan Hand P, Kashmiri SVS, Schlom J (1994)Cancer 78: 1105–13.
Gold DV, DeMartino JA, Shi B, Daugherty BL, Mark GE (1993)Proc Am Assoc Cancer Res 34: 480.
Sawada T, Chung YS, Kondo Y, Satake K, Sowa M, Umeyama K, Ochi I, Ho JJL, Kim YS (1991)Antibody Immunoconjugates and Radiopharmaceuticals 4: 493–99.
Chung Y-S, Kondo Y, Inui A (1993)Proc Am Assoc Cancer Res 34: 474.
Kondo Y, Chung Y-S, Sawada T, Inui A, Yamashita Y, Hirayama K, Nakata B, Ho JJL, Kim YS, Sowa M (1995)Jap J Cancer Res 86: 1072–79.
Jerome KR, Domenech N, Finn OJ (1993)J Immunol 151: 1654–62.
Bu D, Domenech N, Lewis J, Taylor-Papadimitriou J, Finn OJ (1993)J Immunother 14: 127–35.
Wahab ZA, Metzgar RS (1991)Pancreas 6: 307–17.
Jerome KR, Barnd DL, Bendt KM, Boyer CM, Taylor-Papadimitriou J, McKenzie FC, Bast RC, Finn OJ (1991)Cancer Res 51: 2908–16.
Ioannides CG, Fisk B, Jerome KR, Irimura T, Wharton JT, Finn OJ (1993)J Immunol 151: 3693–703.
Wolfel T, Herr W, Coulie P (1993)Int J Cancer 54: 636–44.
Magarian-Blander J, Domenech N, Finn OJ (1993)Annal NY Acad Sci 690: 231–43.
Ogata S, Maimonis PJ, Itzkowitz SH (1992)Cancer Res 52: 4741–46.
Hellstrom I, Garrigues JH, Garrigues V, Hellstrom KE (1990)Cancer Res 50: 2183–90.
Hakomori S-I (1991)Curr Opin Immunol 3: 646–53.
Singhal A, Fohn M, Hakomori S (1991)Cancer Res 51: 1406–11.
Springer GF, Desai PR, Tegtmeyer H, Spencer BD, Scanlon EF (1993)Ann NY Acad Sci 690: 355–57.
Fung PYS, Madej M, Koganty RR, Longenecker BM (1990)Cancer Res 50: 4308–14.
O'Boyle KP, Zamore R, Adlui S, Cohen A, Kemeny N, Welt S, Lloyd KO, Oettgen HF, Old LJ, Livingston PO (1992)Cancer Res 52: 5663–67.
MacLean GD, Reddish M, Koganty RR (1993)Cancer Immunol Immunother 36: 215–22.
Taylor-Papadimitriou J, Stewart L, Burchell J, Beverley P (1993)Ann NY Acad Sci 690: 69–79.
Piera M, de Bolos C, Castro R, Real FX (1993)Int J Cancer 55: 148–52.
Ding L, Lalani E-N, Reddish M (1993)Cancer Immunol Immunother 36: 9–17.
Bashford JL, Robins RA, Price MR (1993)Int J Cancer 54: 778–83.
Rughetti A, Turchi V, Ghetti CA, Scambia G, Pacini PB, Roncucci G, Mancuso S, Frati L, Nuti M (1993)Cancer Res 53: 2457–59.
Lalani E-N, Berdichevsky F, Boshell M, Shearer M, Wilson D, Strauss H, Gendler SJ, Taylor-Papadimitriou J (1991)J Biol Chem 266: 15420–26.
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Kim, Y.S., Gum, J. & Brockhausen, I. Mucin glycoproteins in neoplasia. Glycoconjugate J 13, 693–707 (1996). https://doi.org/10.1007/BF00702333
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DOI: https://doi.org/10.1007/BF00702333