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Radiation grafting of hydrophilic monomers on to plasticized poly(vinyl chloride) sheets

Part 1 Surface characterization and plasticizer migration studies
  • V. Kalliyana Krishnan
  • A. Jayakrishnan
  • Joseph D. Francis
Papers

Abstract

Medical-grade plasticized poly(vinyl chloride) (PVC) sheets were surface modified using gamma-radiation grafting of a combination of hydrophilic monomers based on 2-hydroxyethyl methacrylate (HEMA) and N-vinyl pyrrolidone (NVP). The modified surfaces were evaluated for their surface properties using contact angle measurements, phase-contrast photomicroscopy and scanning electron microscopy. Surface energy calculations of the modified surfaces indicated that the surfaces became highly hydrophilic when grafted with even a 1% (v/v) solution of HEMA-NVP combination in the presence of 0.005m CuSO4. Migration of the plasticizer di(2-ethylhexyl phthalate) (DEHP) from the grafted sheets was examined in hydrocarbon solvents such as n-hexane, n-heptane and n-octane and in extractant media such as cotton seed oil and polyethylene glycol-400 (PEG-400). The migration from modified sheets was found to be <4% of the migration from unmodified control sheets in hydrocarbon solvents at 30° C over a period of 5 h. Accelerated leaching studies in cotton seed oil and PEG-400 demonstrated that virtually no plasticizer migrated out in the former over a period of 96 h whereas the rate of migration in the latter medium showed only a mild reduction. The migration behaviour was Fickian in nature for grafted sheets. The method described may be useful as a simple, versatile technique for preventing plasticizer migration from plasticized PVC for medical applications.

Keywords

DEHP Vinyl Chloride Hydrophilic Monomer Hydrocarbon Solvent Radiation Grafting 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Chapman and Hall Ltd 1990

Authors and Affiliations

  • V. Kalliyana Krishnan
    • 1
  • A. Jayakrishnan
    • 1
  • Joseph D. Francis
    • 2
  1. 1.Biomedical Technology WingSree Chitra Tirunal Institute for Medical Sciences and TechnologyTrivandrumIndia
  2. 2.Department of Polymer Science and Rubber TechnologyUniversity of CochinCochinIndia

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