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Journal of Biological Physics

, Volume 21, Issue 1, pp 67–71 | Cite as

The chirality breaking in the photolysis of leucine enantiomers and 5′CMP

  • Xianming Pan
  • Kongjiang Wang
  • Wenqing Wang
  • Xiangrong Sheng
  • Jilan Wu
Article

Abstract

The inhibition of the photohydrate formation of the cytidine 5′ monophosphate (5′ CMP) under UV irradiation in the presence of the D-, L-leucine in phosphate aqueous solution (pH 7) has been studied. L-leucine demonstrates more effective in preventing 5′ CMP from photohydration than that of D-leucine. This photolysis method can be used instead of NMR spectroscopy to research weak nucleotide-amino acid interaction in aqueous solution especially for nonaromatic acid. A statistical thermodynamic stacking model is proposed to describe the mechanism producing chiral symmetry breaking. The calculated weak interaction energy ε is 1.16kT and 2.05kT for D-, and L-leucine respectively.

Key words

Chirality breaking leucine 5′ CMP weak interaction 

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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Xianming Pan
    • 1
  • Kongjiang Wang
    • 1
  • Wenqing Wang
    • 1
  • Xiangrong Sheng
    • 1
  • Jilan Wu
    • 1
  1. 1.Technical Physics DepartmentPeking UniversityBeijingP.R. China

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