Abstract
Ethyl 2-acetyl-3-amino-4,4,4-trifluoro-2-butenoate was synthesized by treatment of ethyl acetoacetate with CF3CN in the presence of Ni(acac)2. Condensation of the diphenylboron chelate of the former with dimethylformamide dimethylacetal followed by refluxing in ethanol yielded 3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine.
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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1329–1331, July, 1995.
This study was financially supported by the Russian Foundation for Basic Research (Grant No. 94-03-08964).
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Dorokhov, V.A., Vasil'ev, L.S., Surzhikov, F.E. et al. Chelate synthesis of 3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine from ethyl acetoacetate and trifluoroacetonitrile. Russ Chem Bull 44, 1283–1285 (1995). https://doi.org/10.1007/BF00700905
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DOI: https://doi.org/10.1007/BF00700905