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Microorganisms as reagents for transformations of 5α-steroids

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Russian Chemical Bulletin Aims and scope

Abstract

Microbial activation of rings A, B, and C of 5α-steroids is reviewed in connection with the prospects for the use of 5α-steroids as a new starting material for the manufacturing of steroidal medicinal preparations. The combination of chemical synthesis and microbial methods of steroid transformation allows the successful solution of the problem of selective functionalization of steroid molecules, provided the suitable microorganisms are chosen and the conditions of their cultivation are optimized.

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  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913, Moscow, Russian Federation

    N. E. Voishvillo, A. M. Turuta & A. V. Kamernitsky

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  1. N. E. Voishvillo
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  2. A. M. Turuta
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Translated fromIzyestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 567–588, April, 1994.

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Voishvillo, N.E., Turuta, A.M. & Kamernitsky, A.V. Microorganisms as reagents for transformations of 5α-steroids. Russ Chem Bull 43, 515–537 (1994). https://doi.org/10.1007/BF00699817

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