Acta Neuropathologica

, Volume 36, Issue 4, pp 381–385 | Cite as

Cerebral “radiation necrosis”: Vascular and glial features

  • Muhammad M. Husain
  • Julio H. Garcia
Short Original Communications

Summary

Glial and vascular abnormalities in brain, simulating intracranial neoplasia, are described in a patient who received radiation to the pituitary region for treatment of an adenoma, 13 months before death. In addition to the expected changes of cerebral radionecrosis, four interesting features are cited: 1. Diffuse hyperplasia of capillaries in the cerebral cortex with marked endothelial hypertrophy; 2. abundant, large multipolar bizarre cells in the perivascular connective tissues; 3. focal astrocytic proliferation with many cells resembling either Alzheimer type I astrocytes or neoplastic cells, and 4. radiation changes in the non-irradiated brain.

Key words

Brain radiation necrosis Vascular reaction Astroglial reaction 

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References

  1. Arnold, A., Bailey, P.: Alterations in the glial cells following irradiation of the brain in primates. Arch. Path.57, 383 (1954)Google Scholar
  2. Crompton, M. R., Layton, D. D.: Delayed radionecrosis of the brain following therapeutic x-radiation of the pituitary. Brain84, 85 (1961)Google Scholar
  3. Davidoff, L. M., Dyke, C. G., Elsberg, C. A., Tarlov, I. M.: The effect of radiation applied directly to the brain and spinal cord. Experimental investigations on the Macacus Rhesus monkeys. Radiology31, 451 (1938)Google Scholar
  4. Dugger, G. S., Stratford, J. G., Buchard, J.: Necrosis of the brain following roentgen irradiation. Amer. J. Roentgenol.72, 953 (1954)Google Scholar
  5. Eyster, E. F., Nielsen, S. L., Sheline, G. E., Wilson, C. B.: Cerebral radiation necrosis simulating a brain tumor. J. Neurosurg.39, 267 (1974)Google Scholar
  6. Ghatak, N. R., White, B. E.: Delayed radiation necrosis of the hypothalamus. Report of a case simulating recurrent craniopharyngioma. Arch. Neurol. (Chic.)21, 425 (1969)Google Scholar
  7. Lampert, P. W., Davis, R. L.: Delayed effects of radiation on the human central nervous system. Neurology (Minneap.)14, 912 (1964)Google Scholar
  8. Lampert, P., Tom, M. I., Rider, W. D.: Disseminated demyelination of the brain following CO60 (Gamma) radiation. Arch. Path.68, 322 (1959)Google Scholar
  9. Lowenberg-Scharenberg, K., Bassett, R. C.: Amyloid degeneration of the human brain following x-ray therapy. J. Neuropath. exp. Neurol.9, 93 (1950)Google Scholar
  10. McDonald, L. W., Hayes, T. L.: The role of capillaries in the pathogenesis of delayed radionecrosis of brain. Amer. J. Path.50, 745 (1967)Google Scholar
  11. Nielsen, S. L., Kjellberg, R. N., Asbury, A. K., Koehler, A. M.: Neuropathologic effects of proton-beam irradiation in man: evaluation after pituitary irradiation. Acta neuropath. (Berl.)21, 76 (1972)Google Scholar
  12. Pennybacker, J., Russell, D. S.: Necrosis of the brain due to radiation therapy: clinical and pathological observations. J. Neurol. Neurosurg. Psychiat.11, 183 (1948)Google Scholar
  13. Roizin, L.: Pathogenesis of x-radiation effects in the monkey cerebral cortex: histopathologic findings. Brain Res.7, 28 (1968)Google Scholar
  14. Russell, Dorothy, S., Wilson, C. W., Tansley, K.: Experimental radionecrosis of the brain in rabbits. J. Neurol. Neurosurg. Psychiat.12, 187 (1949)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Muhammad M. Husain
    • 1
  • Julio H. Garcia
    • 1
  1. 1.Department of PathologyUniversity of Maryland School of MedicineBaltimoreUSA

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