Abstract
The oxoalkylation of pyridine, 2-methyl-, 4-methyl-, 2,4-dimethyl-, 2,6-dimethylpyridines, quinoline, 4-methylquinoline, isoquinoline, and pyrazine with oxoalkyl radicals generated from 1-methylcyclobutanol or 1-methylcyclopentanol under the action of Pb(OAc)4 or Mn(OAc)3 has been carried out. The reaction products are isomers with 2-(6)- and 4-positions of the oxoalkyl group in theN-heteroaromatic ring. The isomer ratios have been determined as a function of the structure of theN-heteroaromatic compound and the reaction conditions.
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For the preliminary communication, see Ref. 10.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 1923–1927, November, 1993.
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Kapustina, N.I., Sokova, L.L., Ignatenko, A.V. et al. Homolytic oxoalkylation of protonatedN-heteroaromatic compounds. Russ Chem Bull 42, 1839–1843 (1993). https://doi.org/10.1007/BF00698999
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DOI: https://doi.org/10.1007/BF00698999