Abstract
(2S,4S)-4-Arylamino-2-carboxy-5-pyrrolidones were prepared by hydrolysis of dimethyl (2S,4S)-4-arylamino-N-phthaloylglutamates. The protonation constants of the arylamino group in the synthesized compounds were determined. The pyrrolidone ring is stable in acidic or neutral solutions. The relative stability of the pyrrolidone ring in alkaline solutions was studied by IR spectroscopy.
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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2087–2090, December, 1993.
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Krasnov, V.P., Nizova, I.A., Sinitsyna, T.A. et al. Synthesis and study of (2S,4S)-4-arylamino-2-carboxy-5-pyrrolidones. Russ Chem Bull 42, 2001–2004 (1993). https://doi.org/10.1007/BF00698883
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DOI: https://doi.org/10.1007/BF00698883