Summary
Intravenously admistered iodinated contrast media have been demostrated, since early experience with computed tomography of the brain, to improve clinical value of the procedure for detecting intracranial lesions. There is no universal agreement about the amount and the method of administration of the contrast medium. Many authors maintain that the use of large doses gives better results for the diagnosis of tumors and metastases. The purpose of this paper is to evaluate the tolerance of iopamidol administered by rapid intravenous infusion in a large number of patients undergoing contrast enhanced computed tomography to detect brain metastases. The authors examined 969 consecutive adult patients suffering from lung cancer, brain metastases have been detected in 17% of cases. Adverse reactions to contrast media occurred in 3 patients. Non ionic contrast media are recommended in this diagnostic procedure.
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Ambrose J (1972) Computerized transverse axial scanning (tomography). Part 2: Clinical application. Br J Radiol 46: 1023
Paxton R, Ambrose J (1974) The EMI scanner. A brief review of the first 650 patients Br J Radiol 47: 530
New PF, Scott WR, Schnur JA, Davies KR, Taveras JM (1974) Computerized axial tomography with EMI scanner. Radiology 110: 109
Behrooz A-K, Fine M (1987) Application and complications of contrast media in cerebral computed tomography. In: Parvez Z, Moncada R, Sovak M (eds) Contrast media: Biologic effects and clinical application, vol III. CRC Press, Boca Raton, p 51
Ethier R, Scerwin A, Taylor S (1974) Comuterized angiotomography. The use of 100 cc hypaque 60%. Clinical and experimental results. Presented at First Int Symp Comput Axial Tomogr, Montreal
Kramer RA, Janetos GP, Perlstein G (1975) An approach to contrast enhancement in computed tomography of the brain. Radiology 116: 641
Raimoko R, Majurin ML, Virtama P, Kangasneimi P (1982) Value of high contrast medium dose in brain CT. J Comput Assist Tomogr 6: 54
Shalen PK, Hayman CA, Wallace S, Handel SF (1981) Protocol for delayed contrast enhancement in computed tomography of cerebral neoplasia. Radiology 139: 397
Inaba Y, Hiratsuku H, Tsuyumu M, Fujiwara K, Takei H, Oie K, Yamaguchi T, Takasato Y (1978) Sequential delayed enhanced CT in brain tumors. Neuroradiology 16: 549
Paling MR (1979) Contrast dose for enhancement of computed tomograms of the brain. Br J Radiol 52: 62
Leonardi M, Zappoli F, Biasizzo E (1987) Lo studio CT per la ricerca di metastasi con alte dosi di mezzo di contrasto. L'efficacia. Proc Meet Tomografia computerizzata e mezzi di contrasto oggi: quando e perchè. Milano, October 23–24, 1987
Scott WR (1980) Seizures: a reaction to contrast media for computed tomography of the brain. Radiology 137: 359
Lozito JC (1977) Convulsions: a complication of contrast enhancement and computerized tomography. Arch Neurol 34: 649
Witten DM, Hirsch FD, Hartman GW (1973) Acute reactions to urographic contrast medium. AJR 119: 832
Fischer HW (1980) Occurrence of seizures during cranial computed tomography. Radiology 137: 563
Langer M, Felix L, Behrends B, Eichstadt H (1987) Anwendung nichtomscher Kontrastmittel in der Computertomographie. Digit Bilddiagn 7: 25
Fischer HW, Plewes D, Violante M (1981) Contrast media, the blood-brain barrier, and cerebrail flow. Adv Neurol 30: 141
Skalpe IO (1983) Enhancement with water-soluble contrast media in computed tomography of the brain and abdomen. Survey and present state. Acta Radiol [Suppl] 366: 72
Skalpe IO, Hordvik M (1983) Comparison of side effects during cerebral computed tomography with a non ionic (iohexol) and an ionic (metrizoate) contrast medium AJNR 4: 326
Holtes S, Cronqvist S, Renaa T (1983) Contrast enhanced brain CT. Comparison between iohexol and metrizoate. Neuroradiology 24: 213
Tschakrt H (1983) Contrast medium tolerance in computed tomography. Rofo [Suppl] 118: 156
Bagg MN, Horwitz TA, Berter L (1986) Comparison of patient responses to high-and low-osmolality contrast agents injected intravenously. AJR 147: 185
Bonati P, Porrati GC, Rolandi G (1981) Iopamiro and uromiro 300 in brain CAT: a double-blind study. Rays 6: 81
Ramsey RG, Czervionke L, Dommers M, James ME, Huckman MS, Russel EJ (1987) Safety and efficacy of sodium and meglumine ioxaglate (hexabrix) and hypaque M 60% in contrast enhanced computed cranial tomographic scanning. A double blind clinical study. Invest Radiol 22: 56
Pagani JJ, Hayman LA, Bigelow RH, Libshitz HI, Lepke RA, Wallace S (1983) Diazepam prophylaxis of contrast media-induced seizures during computed tomography of patients with brain metastases. AJNR 4: 67
Neuwelt EA, Diehler JT, Vu LH, Hill SA, Michael AJ, Frankel EP (1981) Monitoring of methotrexate delivery in patients with malignant brain tumors after osmotic blood-brain barriers disruption. Ann Int Med 94: 449
Limpke KF, James G, Erhesfeld M (1970) Cerebrovascular permeability of a water-soluble contrast material, hypaque (sodium diatrizoate). Experimental study in dogs. Invest Radiol 5: 79
Hoffa JO, Archer S (1960) X-ray contrast media for cardiovascular angiography. Angiology 11: 244
Rudehili A, Gordon E, Grepe A, Widen L (1983) The epileptogenicity of neuroleptanaesthesia in patients during and after neuroradiological examinations with metrizamide. Acta Anaesthesiol Scand 27: 285
Avrahami E, Weiss-Peretz J, Cohn DF (1987) Focal epileptic activity following intravenous contrast material injection in patients with metastatic brain disease. J Neurol Neurosurg Psychiatry 50: 221
Haslam HA, Cochrene DD, Amundson GM, Johns RD (1987) Neurotoxic complications of contrast computed tomography in children. J Pediatr 111: 837
Nakstod P, Helgetreit A, Aeserud O, Ganes T, Nylerg-Hansen R (1984) Iohexol compared to metrizamide in cervical and thoracic myelography. A randomized double-blind parallel study. Neuroradiolgy 26: 474
Carchietti E, Baldassarre M, Penco T, Leonardi M (1988) Iopamidol 300-induced epilepsy. Intensive treatment and pathogenic hypothesis. A case report. Neuroradiology 30: 256
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Leonardi, M., Lavaroni, A., Biasizzo, E. et al. High-dose contrast-enhanced computed tomography (CECT) with iopamidol in the detection of cerebral metastases. Neuroradiology 31, 148–150 (1989). https://doi.org/10.1007/BF00698843
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DOI: https://doi.org/10.1007/BF00698843