Russian Chemical Bulletin

, Volume 44, Issue 4, pp 631–634 | Cite as

Nucleophilic substitution of halogen in 4-halogenated derivatives of glutamic acid

1. Solvent effect
  • V. P. Krasnov
  • M. A. Koroleva
Physical Chemistry


The reaction of nucleophilic substitution of bromine byp-anisidine in dimethyl (2S,4S)-and (2S,4R)-N-phthaloyl-4-bromoglutamates proceeds according to the SN2 mechanism. The relative reactivity of diastereomers in various solvents was studied.

Key words

glutamic acid diastereoselectivity nucleophilic substitution rate constant solvent effect 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • V. P. Krasnov
    • 1
  • M. A. Koroleva
    • 1
  1. 1.Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesEkaterinburgRussian Federation

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