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A new approach to the synthesis of trifluoromethylated products of the [3,3]-sigmatropic rearrangement

  • Organic Chemistry
  • Published:
Russian Chemical Bulletin Aims and scope

Abstract

CH-acids of general formula CF3CH(X)CF3 (X = CF3, CO2R) react with 2,3-unsaturated alcohols in the presence of bases to give trifluoromethylated products of the [3,3]-sigmatropic rearrangement. These reactions provide a convenient method for the synthesis of 2-alkenyl-2-trifluoromethylmalonates.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 117813, Moscow, Russian Federation

    V. G. Andreev

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  1. V. G. Andreev
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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1273–1277, July, 1994.

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Andreev, V.G. A new approach to the synthesis of trifluoromethylated products of the [3,3]-sigmatropic rearrangement. Russ Chem Bull 43, 1209–1213 (1994). https://doi.org/10.1007/BF00698247

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  • DOI: https://doi.org/10.1007/BF00698247

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