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Physical activity and liver cholesterol

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Summary

The effects of various types and intensities of exercise on hepatic cholesterol and fecal sterol levels of rats fed a high fat diet was investigated. The results demonstrate that liver cholesterol of such animals trained either by running or swimming are lower than non-trained controls.

The concentration of cholesterol in the livers of rats 4 weeks after the termination of training had increased significantly and approached the level of the control animals. Detrained animals also had higher liver cholesterol levels than trained animals. These results suggest that high fat diets produce a progressive accumulation of cholesterol in the livers of rats which can be retarded by exercise. The excretion of sterol in the fecals was significantly higher in the trained animals. The elevated excretion of cholesterol may be one of the methods by which exercise retards the accumulation of cholesterol in the livers of rats fed high fat diets.

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Authors and Affiliations

  1. Exercise Physiology Laboratory, Department of Physical Education for Men Washington State University, Pullman, Washington, USA

    Philip D. Gollnick & Steven W. Simmons

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  1. Philip D. Gollnick
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  2. Steven W. Simmons
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Additional information

This investigation supported by Research Grant HE 08262 from the National Heart Institute, National Institutes of Health, U.S. Public Health Service.

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Gollnick, P.D., Simmons, S.W. Physical activity and liver cholesterol. Int. Z. Angew. Physiol. Einschl. Arbeitsphysiol. 23, 322–330 (1967). https://doi.org/10.1007/BF00698041

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  • DOI: https://doi.org/10.1007/BF00698041

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