Abstract
Parental-to-F1-hybrid liver tissue grafts in like-sex donor-recipient combinations survive indefinitely, although several F1 recipients demonstrate an immunological response to the parental graft. Female F1 recipients, particularly those carrying theH-2 b haplotype, respond vigorously to male parental liver grafts. However F1 female responses to male parental liver tissue grafts differ substantively from the responses of parental females to syngeneic male grafts. C3H male liver grafts are rejected vigorously by F1 females as long as the F1 carries theH-2 b haplotype. These findings support previous reports of strong immunological responses to C3H H-Y antigen in female F1 and C3H.SW animals, a response which is absent in C3H females. Female F1 hybrids carrying theH-2 b haplotype do not reject grafts of B10 or B6 male liver as rapidly as do B10 or B6 parental females. This reduced F1 response may be related to the formation of hybrid antigens and consequent alteration of the anti-H-Y response. Alternatively, cells that specifically suppress the anti-H-Y response may be present in F1 hybrids. Factors responsible for suppression appear to be controlled by non-MHC antigens, at least in (OH x B6 or B10) F1 hybrids.
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References
Bailey, D. W.: Allelic forms of a gene controlling the female immune response to the male antigen in mice.Transplantation 11: 426–428, 1971
Bailey, D. W. and Hoste, J.: A gene governing the female immune response to the male antigen in mice.Transplantation 11: 404–407, 1971
Cudkowicz, G. and Bennett, M.: Peculiar immunology of bone marrow allografts. II. Rejection of parental grafts by resistant F1 hybrid mice.J. Exp. Med. 134: 1513–1528, 1971
DeMott-Friberg, R., Beals, T. F., and Schultz, J. S.: (H-2) and background influences on tissue grafts across the H-Y barrier.Immunogenetics 9: 369–381, 1979
Eichwald, E. J., Wetzel, B., and Lustgraaf, E. C.: On the hybrid effect in skin grafting.Transplantation 3: 764–766, 1965
Gasser, D. L. and Silvers, W. K.: Genetic control of the immune response in mice. III. An association between (H-2 d) type and reaction to H-Y.J. Immunol. 106: 875–876, 1971
Gasser, D. L. and Silvers, W. K.: Genetics and immunology of sex-linked antigens.Adv. Immunol. 15: 215–247, 1972
Hellström, K. E.: Growth inhibition of sarcoma and carcinoma cells of homozygous origin. Science143: 477–478, 1964
Králová, J. and Démant, P.: Expression of the H-Y antigen on thymus cells and skin: differential genetic control linked toK end ofH-2.Immunogenetics 3: 583–594, 1976
LaFuse, W. P., McCormick, J. F., and David, C. S.: Serological and biochemical identification of hybrid la antigens.J. Exp. Med. 151: 709–715, 1980
Mood, A. M.: Introduction to the Theory of Statistics, McGraw Hill, New York, 1950
Nakano, K., Nakamura, I., and Cudkowicz, G.: Generation of F1 hybrid cytotoxic T lymphocytes specific for self H-2.Nature 289: 559–563, 1981
Sandrin, M. S., Tobias, G. H., McKenzie, I. F. C., and Hämmerling, G. J.: Alterations in the Expression of Ia Antigens in F1 hybrid mice.Immunogenetics 14: 507–516, 1981
Schultz, J. S., Beals, T. F., and Petraitis, F. P.: Tissue graft rejection in mice. I. Contributions ofH-2 and non-H-2 genetic barriers.Immunogenetics 3: 85–96, 1976
Schultz, J. S., Beals, T. F., and DeMott-Friberg, R.: Tissue graft rejection in mice. V. Survival, rejection, or proliferation across minor barriers.Immunogenetics 6: 585–595, 1978
Schultz, J. S., DeMott-Friberg, R., and Beals, T. F.: Immunogenetic control of the response of female mice to male tissue grafts.Immunogenetics 12: 199–205, 1981
Schultz, J. S., DeMott-Friberg, R., and Beals, T. F.: Liver tissue graft rejection in murine major histocompatibility complex mutants.Immunogenetics 15: 357–364, 1982
Silvers, W. K. and Billingham, R. E.: Genetic background and expressivity of histocompatibility genes.Science 158: 118–119, 1967
Silvers, W. K. and Wachtel, S. S.:H-Y-antigen: behavior and function. Science 195: 956–960, 1977
Simpson, E.: The role ofH-Y as a minor transplantation antigen.Immunol. Today 3: 97–106, 1982
Simpson E. and Gordon, R. D.: Responsiveness toH-Y antigen,Ir gene complementation and target cell specificity.Immunol. Rev. 35: 59–75, 1977
Simpson, E., McLaren, A., and Chandler, P.: Evidence for two male antigens in mice.Immunogenetics 15: 609–614, 1982
Snell, G. D.: Histocompatibility genes of the mouse. I. Demonstration of weak histocompatibility differences by immunization and controlled tumor dosage.J. Natl. Cancer Inst. 20: 787–824, 1958
Stimpfling, J. H. and Reichert, A. E.: Male-specific graft rejection and theH-2 locus.Transplantation 12: 527–531, 1971
von Boehmer, H., Haas, W., and Jerne, N. K.: Major histocompatibility complex-linked immuneresponsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.Proc. Natl. Acad. Sci. U.S.A. 75: 2439–2442, 1978
Wachtel, S. S., Gasser, D. L., and Silvers, W. Y.: Male-specific antigen: modification of potency by the H-2 locus in mice.Science 181: 862–863, 1973
Wicker, L. S. and Hildemann, W. H.: Two distinct high immune response phenotypes are both controlled byH-2 genes mapping inK orI-A.Immunogenetics 12: 253–265, 1981
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Schultz, J.S., DeMott-Friberg, R. & Beals, T.F. Hybrid immune response to parental liver tissue grafts. Immunogenetics 17, 465–473 (1983). https://doi.org/10.1007/BF00696870
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DOI: https://doi.org/10.1007/BF00696870