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MHC epitopes of Ks and Dd restrict the same population of cytolytic T lymphocytes

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Abstract

When A. SW (H-2 s) mice are immunized with B10.S (H-2 S) epidermal cells, cytolytic T lymphocytes are evoked that efficiently lyse B10.D2 (H-2 d) as well as B10.S target cells. Immunogenetic analysis of this apparent H-2-unrestricted killing revealed that the most plausible explanation was a sharing of an H-2-restricting epitope by H-2KS and H-2Dd molecules.

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Author notes

  1. John D. Tyler

    Present address: Department of Surgery, Washington University School of Medicine, 4960 Audubon, 63110, St. Louis, Missouri

Authors and Affiliations

  1. Department of Immunology, Mayo Clinic and Mayo Medical School, 55905, Rochester, Minnesota

    John D. Tyler & Chella S. David

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  1. John D. Tyler
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  2. Chella S. David
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Tyler, J.D., David, C.S. MHC epitopes of Ks and Dd restrict the same population of cytolytic T lymphocytes. Immunogenetics 17, 457–464 (1983). https://doi.org/10.1007/BF00696869

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  • DOI: https://doi.org/10.1007/BF00696869

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