Archives of Toxicology

, Volume 43, Issue 1, pp 3–7 | Cite as

The no-effect level, an old bone of contention in toxicology

  • Gerhard Zbinden


This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Information on the mechanisms of the biologic effects of chemicals should, whenever possible, be used preferentially for the assessment of human risk and should therefore also be considered for the establishment of the ADI.


Toxicity Cancer Research Biologic Effect Environmental Chemical Toxicology 
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  1. 1.
    Joint FAO/WHO Expert Committee on Food Additives, 17th Report, WHO Technical Report Series, No. 539, Geneva 1974Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Gerhard Zbinden
    • 1
  1. 1.Institute of Toxicology, Federal Institute of Technology and University of ZurichSchwerzenbachSwitzerland

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