Summary
The epithelium of human chorion laeve from pregnancies complicated by diabetes mellitus was examined under the light and electron microscopy.
In comparison with normal chorion laeve, the epithelium of chorion laeve in diabetes mellitus shows the following morphological changes:
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1.
The trophoblast cells display more microvilli and cell processes on their surface.
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2.
Trophoblast cells with different cytoplasmic characteristics can be seen. Some display few organelles and large glycogen depositions; other are rich in organelles. Furthermore, some cells with electron dense filaments and few cell organelles can be found.
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3.
Necrotic cells are frequently present in the outer epithelial layers.
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4.
The intercellular spaces in the epithelial layers near the basement
membrane are narrower.
Since vasculopathy of the decidual arteries with disturbance of blood circulation is often found in pathological pregnancies, we assume that the morphological changes found are due to deficiency in nutrient and oxygen supply.
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Reference
Bartels H, Wang T (1983) Intercellular junctions in the human fetal membranes: A freeze-fracture study. Anat Embroyol 166:103–120
Benedetti WL, Sala MA, Alvares H (1973) Histochemical demonstration of enzymes in the umbilical cord and membranes of human term pregnancy. Eur J Obstet Gynec 3:185–189
Bourne G (1962) The human amnion and chorion. Lloyd-Luke, London
Brightman MW, Reese TS (1969) Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol 40:648–677
Claude P (1978) Morphological factor influencing transepithelial permeability: A model for the resistance of the zonula occludens. J Membr Biol 39:219–232
De Wolf F, Brosens I, Renaer M (1980) Fetal growth retardation and maternal arterial supply of the human placenta in the absence of sustained hypertension. Br J Obstet Gynaecol 87:678–685
Emmerich P, Birke R, Gödel E (1975) Beitrag zur Morphologie der myometrialen und dezidualen Arterien bei normalen Schwangerschaften, EPH-Gestose und mütterlichem Diabetes mellitus. Pathol Microbiol 43:38–61
Farquhar MG, Palade GE (1963) Junctional complexes in various epithelia. J Cell Biol 17:375–412
Ho PC, Haynes WDG, Ing RMY, Jones WR (1982) Histological ultrastructural and immunofluorescence studies on the amnionchorionic membrane. Placenta 3:109–126
Hoyes AD (1971) Ultrastructure of the mesenchymal layers of the human chorion laeve. J Anat (Lond) 109:17–30
Kaufmann P (1972) Untersuchungen über die Langhanszellen in der menschlichen Placenta. Z Zellforsch 128:283–302
Keirse MJNC, Turnbull AC (1976) The fetal membranes as a possible source of amniotic fluid prostaglandins. Br J Obstet Gynaecol 83:146–151
Lister UM (1968) Ultrastructure of the human amnion, chorion and fetal skin. J Obstet Gynaec Brit Cwlth 75:327–341
McNutt NS, Weinstein RS (1973) Membrane ultrastructure at mammalian intercellular junctions. In: Butler JAV, Noble D (eds). Pergamon Press, Oxford New York Toronto Sydney Braunschweig, Vol 26, pp 47–101
Minh HN, Douvin D, Smadja A, Orcel L (1980) Fetal membrane morphology and circulation of the liquor amnii. Eur J Obstet Gynec reprod Biol 10:213–223
Minh HN, Smadja A, De St Maur PP, Orcel L (1981) Electron microscopic study of intercellular canalicular systems in the parietal fetal membranes. Br J Obstet Gynaecol 88:1104–1109
Murphy BEP (1977) Chorionic membrane as an extraadrenal source of foetal cortisol in human amniotic fluid. Nature 226:179–181
Petry G (1963) Die Morphologie der außerhalb der Placenta bestehenden feto-maternen Kontakte. Arch Gynäkol 198:74–81
Poisner AM, Wood GM, Poisner R, Inagami T (1981) Localization of renin in trophoblasts in human chorion laeve et term pregnancy. Endocrinology 109:1150–1155
Robertson WB (1976) Uteroplacental vasculature. J Clin Pathol Suppl 10:9–17
Robertson WB, Brosens I, Dixon G (1967) The pathological response of the vessels of the placental bed to hypertensive pregnancy. J Pathol Bact 93:581–592
Robertson WB, Brosens I, Dixon G (1975) Uteroplacental vascular pathology. Eur J Obstet Gynec Reprod Biol 5:47–65
Schmidt W, Pfaller K, Klima G (1982) Licht- und elektronenmikroskopische Untersuchungen an den Eihäuten des Menschen. 2. Chorion und Dezidua. Zbl Gynäkol 104:1137–1148
Sheppard BL, Bonnar J (1976) The ultrastructure of the arterial supply of the human placenta in pregnancy complicated by fetal growth retardation. Br J Obstet Gynaecol 83:948–959
Staehelin LA (1974) Structure and function of intercellular junctions. Int Rev Cytol 39:191–283
Symonds EM, Skinner SL, Stanley MA, Kirkland JA, Ellis RC (1970) An investigation of the cellular source of renin in human chorion. J Obstet Gynaecol Br Cwlth 77:885–890
Thliveris JA, Speroff L (1977) Ultrastructure of the placenta villi, chorion laeve and decidua parietalis in normal and hypertensive pregnant women. Am J Obstet Gynecol 129:492–498
Wang T, Schneider J (1983) Fine structure of human chorionic membrane: Ultrastructural and histochemical examinations. Arch Gynecol 233:187–198
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Supported by the Deutsche Forschungsgemeinschaft (Az: Schn. 105/7-1)
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Wang, T. Epithelium of the human chorion laeve in diabetes mellitus. Vichows Archiv A Pathol Anat 402, 289–296 (1984). https://doi.org/10.1007/BF00695082
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DOI: https://doi.org/10.1007/BF00695082