Virchows Archiv A

, Volume 402, Issue 1, pp 99–106 | Cite as

Renal dysplasia of the sacral region: Metanephric dysplastic hamartoma of the sacral region

  • Cleto Cozzutto
  • Vincenzo Stracca-Pansa
  • Francesco Salano
Case Report


We believe this to be the third reported case of an unusual congenital sacral tumor-like lesion characterized histologically by the presence of dysplastic and immature renal-like tissue with a predominant glomerular and tubular structure.

This lesion appears important in the differential diagnosis of extrarenal nephroblastoma, and should be regarded as a dysplastic overgrowth.

An origin from mesonephric or metanephric remnants is suggested.

Key words

Sacral region Retroperitoneum Kidney congenital abnormalities Kidney, dysplasia Kidney, neoplasms 


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  1. Akhtar M, Kott E, Brooks B (1977) Extrarenal Wilms tumor. Report of a case and review of the literature. Cancer 40:3087–3091Google Scholar
  2. Allan E (1975) Nephrogenic adenoma of the bladder. J Urol 113:35–41Google Scholar
  3. Bernstein J (1974) The morphogenesis of renal parenchymal maldevelopment (Renal dysplasia). Ped Clin N Am 18:395–407Google Scholar
  4. Bittencourt AL, Britto JF, Fonseca LE (1981) Wilms' tumor of the uterus. The first report of the literature. Cancer 47:2496–2499Google Scholar
  5. Boccon-Gibod L, Petit J (1975) Le concept de dysplasie renal. A propos de 67 observations. Ann Anat Pathol 20:213–230Google Scholar
  6. Burgess SB (1969) Supernumerary kidney. Report of a case. Arch Pathol 69:154–157Google Scholar
  7. Cozzutto C, Lazzaroni-Fossati F (1980) Renal dysplasia with sacral perineal location. J Urol 124:901–903Google Scholar
  8. Dehner L (1975) Pediatric Surgical Pathology. St Louis. The CV Mosby CompanyGoogle Scholar
  9. Drake M, Franciosi RA, Spencer B, Baker T (1976) Ectopic renal tissue in the region of sacrum. A case report. Am J Pathol 182:8A (Abstract)Google Scholar
  10. Ericsson NO, Ivemark EI (1958a) Renal dysplasia and pyelonephritis in infants and children. Part I Arch Pathol 66:255–263Google Scholar
  11. Ericsson NO, Ivemark EI (1958b) Renal dysplasia and pyelonephritis in infants and children. Part II Primitive ductules and abnormal glomeruli. Arch Pathol 66:264–269Google Scholar
  12. Goldman RL (1972) Nephrogenic metaplasia (nephrogenic adenoma, adenomatoid tumor) of the bladder. J Urol 108:565–567Google Scholar
  13. Gonzales-Crussi F, Winkler RF, Mirkin DL (1978) Sacrococcygeal teratomas in infants and children. Relationship of histology to prognosis in 40 cases. Arch Pathol Lab Med 102:420–425Google Scholar
  14. Greville Williams GE (1963) Renal angiomyolipoma with an epithelial component. J Pathol Bacteriol 86:223–225Google Scholar
  15. Gruenwald P (1942) Tissue anomalies of probable neural crest origin in a twenty millimeter human embryo with myeloschisis. Arch Pathol 31:489–492Google Scholar
  16. Kissane JM (1975) Pathology of Infancy and Childhood. The C.V. Mosby Company, St. Louis, p 582Google Scholar
  17. Kissane JM (1974) Congenital malformations. In: Heptinstall R (ed) Pathology of the Kidney, 2th edi. Little Brown and Company, Boston, pp 63–117Google Scholar
  18. Malik T, Malik G, Diesch G (1967) Retroperitoneal teratoma with nephroblastic tissue as the main component. Int Surg 47:246–249Google Scholar
  19. Marsden HB, Lawler W (1982) Wilms' tumor and renal dysplasia: a hypothesis. J Clin Pathol 35:1069–1073Google Scholar
  20. Milliser RV, Greenberg SR, Neiman BH (1969) Heterotopic renal tissue in the human adrenal gland. J Urol 192:280–284Google Scholar
  21. Milliser RV, Greenberg SR, Neiman BH (1972) Heterotopic renal tissue in the human heart. J Urol 108:21–24Google Scholar
  22. McCrory WW (1972) Developmental Nephrology. Cambridge Massachusetts, Harvard University PressGoogle Scholar
  23. Nicholson GW (1934) Studies on tumor formation. Kidney in a teratoma. Guys Hosp Rep 84:140–156Google Scholar
  24. Nogales FF, Ortega I, Rivera F, Armas JR (1980) Metanephrogenic tissue in immature ovarian teratoma. Am J Surg Pathol 4:297–299Google Scholar
  25. Novak ER, Woodruff JD (1974) Novak's Gynecologic and Obstetric Pathology. WB Saunders Company, Philadelphia, London, Toronto, pp 321–322Google Scholar
  26. O'Shea PA, Callaghan JF, Lawlor JB, Reddy VC (1981) “Nephrogenic adenoma”: an unusual metaplastic change of urothelium. J Urol 125:249–252Google Scholar
  27. Risdon RA (1971) Renal dysplasia. J Clin Pathol 24:57–71Google Scholar
  28. Schnoy N, Leistenschneider W (1982) Tumor of mesonephric origin in a diverticulum of the urethra. An ultrastructural study. Virchows Arch [Pathol Anat] 397:335–345Google Scholar
  29. Sussman EB, Brice M, Gray GF (1974) Nephrogenic metaplasia of the bladder. J Urol 111:34–35Google Scholar
  30. Thompson MR, Emmanueal IG, Campbell MS, Zachary RB (1973) Extrarenal Wilms tumor. J Ped Surg 8:37–41Google Scholar
  31. Tokumitsu S, Tokumitsu K, Takeya M, Takeuchi T (1981) Developmentally heterotopic urogenital tissues in a retroperitoneal lipoma with hematopoiesis. Acta Pathol Jpn 31:289–297Google Scholar
  32. Valdisserri Ro, Yunis EJ (1981) Sacrococcygeal teratomas: a review of 68 cases. Cancer 48:217–221Google Scholar
  33. Vellios F, Garrett RA (1961) Congenital unilateral multicystic disease of the kidney. A clinical and anatomic study of seven cases. Am J Clin Pathol 35:244–254Google Scholar
  34. Wade-Evans T, Langley FA (1961) Mesonephric tumors of the female genital tract. Cancer 14:711–725Google Scholar
  35. Ward S, Dehner LP (1974) Sacrococcygeal teratoma with nephroblastoma. A variant of extra-gonadal teratoma in childhood. Cancer 33:1355–1363Google Scholar
  36. Willis RA (1958) The Borderline of Embryology and Pathology. London Butterworth and Co, London TD, p 330Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Cleto Cozzutto
    • 1
  • Vincenzo Stracca-Pansa
    • 2
  • Francesco Salano
    • 3
  1. 1.Departments of PathologyGiannina Gaslini Institute Children's and Women's HospitalGenoaItaly
  2. 2.Ospedale CivileVicenza
  3. 3.Department of SurgeryOspedale CivileVicenzaItaly

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