Virchows Archiv A

, Volume 402, Issue 1, pp 35–45 | Cite as

Oral granular cell lesions

An immunohistochemical study with emphasis on intermediate-sized filaments proteins
  • Pieter Slootweg
  • Peter de Wilde
  • Peter Vooijs
  • Frans Ramaekers


Six cases of oral granular cell lesions were studied with respect to intermediate-sized filaments (IF), peanut lectin binding (PNL) and muramidase activity by means of the peroxidase antiperoxidase technique. The tumours included three granular cell myoblastomas of the tongue (GCM) two cases of congenital gingival granular cell tumour (CGGT) and one granular cell ameloblastoma (GCA). Every tumour studied showed intracytoplasmic PNL binding whereas muramidase was negative in all cases. Vimentin expression was demonstrated in the CGGT and to a lesser extent in the GCM, but was absent in the GCA which was positive for keratin. Desmin and glial fibrillary acidic protein (GFAP) were not present in any of the lesions. These data demonstrate that PNL binding might be considered to be a common feature of granular cells regardless of their histogenesis. Lysosomes are supposed to represent the intracellular binding sites for this marker. Moreover it is shown that histomorphological identity between the granular cells of CGGT and GCA does not signify identity in histogenesis since the former are of mesenchymal derivation while the latter, from their intermediate filament protein types appear to originate from epithelium.

Key words

Congenital gingival granular cell tumor Granular cell myoblastoma Granular cell ameloblastoma Peanut lectin Intermediate-sized filaments 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Pieter Slootweg
    • 1
  • Peter de Wilde
    • 1
  • Peter Vooijs
    • 2
  • Frans Ramaekers
    • 1
  1. 1.Department of Oral PathologyState UniversityUtrechtThe Netherlands
  2. 2.Department of PathologyUniversity of NijmegenNijmegenThe Netherlands

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