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Journal of Comparative Physiology B

, Volume 156, Issue 6, pp 839–844 | Cite as

The role of adenosine in the isolatedRana ridibunda heart

  • A. Lazou
  • Is. Beis
Article

Summary

In an attempt to study the metabolic role of adenosine in the amphibian heart, we perfusedRana ridibunda hearts under conditions of decreased oxygen supply or increased oxygen demand and measured the rate of adenosine appearance as well as the concentrations of adenine nucleotides. Anoxia was associated with a significant increase in the myocardial and perfusate concentration of adenosine and its degradation products, inosine and hypoxanthine, while changes were also observed in the concentrations of adenine nucleotides and creatine phosphate. Furthermore, adenosine production inRana ridibunda hearts was enhanced under conditions of increased cardiac work induced by perfusion pressure elevation. Adenosine production was inversely proportional to the energy charge value calculated from the tissue content of adenine nucleotides under conditions of anoxia and increased heart work. The results are in accordance with the proposed role of adenosine as a physiological metabolic vasodilator in the coronary circulation of the mammalian heart and support the hypothesis that adenosine can be involved in regulating blood vessel resistance inRana ridibunda heart under conditions of low myocardial oxygen tension. Thus it appears that adenosine could act as a vasodilatory substance inRana ridibunda heart.

Keywords

Adenosine Inosine Hypoxanthine Adenine Nucleotide Creatine Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • A. Lazou
    • 1
  • Is. Beis
    • 1
  1. 1.Laboratory of Animal Physiology, Department of Zoology, Science SchoolUniversity of ThessalonikiThessalonikiGreece

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