Glycogen accumulations in the cerebral cortex in Alzheimer's disease
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The fine structure of granular glycogen bodies (GGB) within the grey matter of the temporal cortex of 11 patients with Alzheimer's disease is described. GGB measure up to 50 μm in diameter and consist of densely packed α or β glycogen granules (never both), neither of which are membrane bound. They were noted in axons, both myelinated and unmyelinated (sometimes close to the dystrophic neurites of senile plaques), and also in other processes of indeterminate origin. Their appearance may relate to disturbances of axonal transport resulting from damage to terminals within evolving senile plaques.
Key wordsGlycogen Cerebral cortex Alzheimer's disease
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- Benson DF, Kuhl DE, Hawkins RA, Phelps ME, Cummings JL, Tsai SY (1983) The fluorodeoxyglucose 18F scan in Alzheimer's disease and multi-infarct dementia. Arch Neurol 40:711–714Google Scholar
- Foster NL, Chase TN, Fedio P, Patronas NJ, Brooks RA, Di Chiro G (1983) Alzheimer's disease: focal changes shown by positron emission tomography. Neurology 33:961–965Google Scholar
- Gertz HJ, Cervos-Navarro J, Frydl V, Schultz F (1985) Glycogen accumulation of the aging human brain. Mech Ageing Dev 31:25–35Google Scholar
- Kornfeld M, Lebaron M (1984) Glycogenosis type VIII. J Neuropathol Exp Neurol 43:568–579Google Scholar
- Mann DMA, Yates PO, Marcyniuk B (1985) Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of Alzheimer's type and Down's syndrome in middle age. J Neurol Sci 69:139–159Google Scholar
- Neary D, Snowden JS, Mann DMA, Bowen DM, Sims NR, Northen B, Yates PO, Davison AN (1986) Alzheimer's disease: a correlative study. J Neurol Neurosurg Psychiatry 49:229–237Google Scholar
- Palmucci L, Anzil AP, Christomanou H (1982a) On the association of excess glycogen granules and polyglucosan bodies (corpora amylacea) in astrocytes of a 17-year-old patient with a neurologic disease of unknown origin: clinical, biochemical and ultrastructural observations. Clin Neuropathol 1:2–10Google Scholar
- Palmucci L, Anzil AP, Luh S (1982b) Intra-astrocytic glycogen granules and corpora amylacea stain positively for polyglucosans: a cytochemical contribution on the fine structural polymorphism of particulate polysaccharides. Acta Neuropathol (Berl) 57:99–102Google Scholar
- Resibois-Gregoire A, Dourov A (1966) Electron microscopic study of a case of cerebral glycogenosis. Acta Neuropathol (Berl) 6:70–79Google Scholar
- Sumpter PQ, Mann DMA, Davies CA, Yates PO, Snowden JS, Neary D (1986a) An ultrastructural analysis of the effects of accumulation of neurofibrillary tangle in pyramidal cells of the cerebral cortex in Alzheimer's disease. Neuropathol Appl Neurobiol 12:305–319Google Scholar
- Sumpter PQ, Mann DMA, Davies CA, Snowden JS, Neary D, Yates PO (1986b) A quantitative study of ultrastructural changes in pyramidal cells of the cerebral cortex in Alzheimer's disease and their relationship to dementia. Neuropathol Appl Neurobiol 12:321–323Google Scholar